Evidence for the evolution of a tunnel to sequester CO, not to maximize its transport (Angewandte Chemie, May 2024)
Jakob Ruickoldt, Jae-Hun Jeoung, Julian Kreibich, Frank Lennartz, and Holger Dobbek together with colleagues from the group of Reinhard Schomäcker (UniSyscat, TU Berlin, Germany) used X-ray protein crystallography, phylogenesis, and kinetic methods to studied the properties of the CO transport tunnel connecting the two catalytic sites in the bifunctional complex CODH/ACS: reduction of CO2 in CODH and condensation of CO with a methyl moiety and CoA to acetyl-CoA in ACS. The results show that the complex CODH/ACS evolved the tunnel to sequester CO rather than to maximize turnover.
Jakob Ruickoldt, Jae-Hun Jeoung, Maik A. Rudolph, et al (2024) Ang. Int Ed Chem DOI: 10.1002/anie.202405120