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Humboldt-Universität zu Berlin - Experimentelle Biophysik

Papers

2020

Friedrich, D., Brünig, F.N., Nieuwkoop A.J., Netz R.R., Hegemann P. and Oschkinat H. (2020) Collective exchange processes reveal an active site proton cage in bacteriorhodopsin. Communications Biology 3.4. doi.org/10.1038/s42003­­-019-0733-7

 

2019

Penzkofer, A., Silarpetere, A., Hegemann, P. (2019) Photocycle Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor Quasar1. Int. J. Mol. Sci. 21, 160 https://doi.org/10.3390/ijms21010160 

 

Ritter, E., Puskar, L., Kim, S.Y., Park, J.H., Hofmann K.-P., Bartl F., Hegemann P., and Schade, U. (2019) Féry IR-spectrometer for Single-shot analysis of protein dynamics. J. Phys. Chem. Lett. 10, 24, 7672-7677. doi.org/10.1021/acs.jpclett.9b03099

 

Penzkofer, A., Silapetere, A., and Hegemann, P. (2019) Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1. Int. J. Mol. Sci. 20, 4086; doi.org/10.3390/ijms20174086

 

Oppermann J., Fischer P., Salipetere A., Liepe B., Rodriguez-Rozada S., Flores-Uribe J.F., Peter E., Sharon I., Keidel A., Vierock J., Kaufmann J., Broser M., Luck M., Bartl F., Hildebrandt P., Wiegert J.S., Béjà O., Hegemann P., Wietek J. (2019) MerMAIDs: A novel family of metagenomically discovered, marine, anion-conducting and intensely desensitizing channelrhodopsins. Nature Comm. 10(1):3315. doi.org/10.1038/s41467-019-11322-6

 

Giliberti V, Polito R, Ritter E, Broser M, Hegemann P, Puskar L, Schade U, Zanetti-Polzi L, Daidone I, Corni S, Rusconi F, Biagioni P, Baldassarre L, Ortolani M. (2019) Tip-enhanced Infrared Difference-Nanospectroscopy of the Proton Pump Activity of Bacteriorhodopsin in Single Purple Membrane Patches. Nano Lett. 19(5):3104-3114. doi.org/10.1021/acs.nanolett.9b00512. Epub 2019 Apr 17.

 

Böhm M., Boness D., Fantisch E., Erhard, H., Frauenholz J., Kowalzyk Z., Marcinkowski N., Kateriya S., Hegemann P. and Kreimer G. (2019) Phosphorylation of Channelrhodopsin-1 responds to different physiological stimuli and influences the phototactic behavior of Chlamydomonas. Plant Cell 31(4):886-910. doi: 10.1105/tpc.18.00936.

 

Krause, B.S., Kaufmann, J.C.D., Kuhne, J., Vierock, V., Huber, T., Sakmar, T.P., Gerwert, K., Bartl, F.J., and Hegemann, P. (2019) Tracking pore hydration in channelrhodopsin by site-directed infrared-active azido probes. Biochemistry 58(9): 1275-1286. doi: 10.1021/acs.biochem.8b01211.

 

Jens Kuhne*, Johannes Vierock*, Stefan Tennigkeit, Jonas Wietek, Dennis Petersen, Max-Aylmer Dreier, Jonas Schartner, Konstantin Gavrilijuk, Samir F. El-Mashtoly, Peter Hegemann and Klaus Gerwert. (2019) A unifiying photocycle model unraveling light adaptation and temporal evolution of cation conductance in Channelrhodopsin-2 Proc Natl Acad Sci USA. 116(19):9380-9389. doi: 10.1073/pnas.1818707116.

 

Vogt, A., Silapetere, A., Grimm, C., Heiser, F., Möller, M.A. and Hege­mann, P. (2019) Engineered Passive Potassium Conductance in the KR2 Sodium Pump. Biophys. J. 116, 1941-1951. doi.org/10.1016/j.bpj.2019.04.001

 

Mukherjee S, Hegemann P, Broser M. (2019) Enzymerhodopsins: novel photoregulated catalysts for optogenetics. Curr Opin Struct Biol. 2019 Apr 4;57:118-126. doi: 10.1016/j.sbi.2019.02.003. [Epub ahead of print] Review. PMID: 30954887

 

Luck M, Velázquez Escobar F, Glass K, Sabotke MI, Hagedorn R, Corellou F, Siebert F, Hildebrandt P, Hegemann P., Photoreactions of the Histidine Kinase Rhodopsin Ot-HKR from the Marine Picoalga Ostreococcus tauri.Biochemistry. 2019 Apr 9;58(14):1878-1891. doi: 10.1021/acs.biochem.8b01200. Epub 2019 Mar 21. PMID: 30768260

 

Fudim R., Szczepek M., Vierock J., Vogt A., Schmidt A., Kleinau G., Fischer P., Bartl FJ, Scheerer P., and Hegemann P. (2019) Design of a light-gated proton channel based on the high-resolution structure of Coccomyxa rhodopsin Sci. Signal. 12, eaav4203; doi: 10.1126/scisignal.aav4203

 

 

 

2018

Penzkofer A, Hegemann P, Kateriya S (2018) Organic dyes in optogenetics Organic Lasers and Organic Photonics. Edited by F J Duarte. Bristol: IOP Publishing.  pp 13, 1-114

https://iopscience.iop.org/book/978-0-7503-1572-2.pdf

 

Bernal Sierra, Y.A.*, Rost, B.R.*, Pofahl, M.*, Fernandes, A.M., Kopton, R.A., Moser, S., Holtkamp, D., Masala, N., Beed, P., Tukker, J.J., et al. (2018). Potassium channel-based optogenetic silencing. Nature Communications 9, 4611. *equal contribution

https://www.nature.com/articles/s41467-018-07038-8

 

Oda, K., Vierock, J., Oishi, S., Rodriguez-Rozada, S., Taniguchi, R., Yamashita, K., Wiegert, J.S., Nishizawa, T., Hegemann, P., Nureki, O. (2018) Crystal structure of the red light-activated channelrhodopsin Chrimson. Nature Comm. 9(1):3949. doi: 10.1038/s41467-018-06421-9.

https://www.nature.com/articles/s41467-018-06421-9

 

Scheib, U., Broser, M., Constantin, O.M., Yang, S., Gao, S., Mukherjee, S., Stehfest, K., Nagel, G., Gee, C.E., Hegemann, P. (2018) Rhodopsin-cyclases for light-induced cGMP & cAMP production and 2.3 Å structure of an adenylyl cyclase domain. Nature Comm. 9(1):2046. doi: 10.1038/s41467-018-04428-w.

https://www.nature.com/articles/s41467-018-04428-w

 

Grimm, C., Silapetere, A., Vogt, A., Bernal Sierra, Y.A., Hegemann, P. (2018) Electrical properties, ion selectivity and optogenetic potential of an engineered light-driven sodium pump eKR2. Sci Rep. 8:9316. doi: 10.1038/ s41598-018-27690-w.

https://www.nature.com/articles/s41598-018-27690-w

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1982 - 1995