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Humboldt-Universität zu Berlin - Experimentelle Biophysik

Papers

2019

Giliberti V, Polito R, Ritter E, Broser M, Hegemann P, Puskar L, Schade U, Zanetti-Polzi L, Daidone I, Corni S, Rusconi F, Biagioni P, Baldassarre L, Ortolani M. (2019) Tip-enhanced Infrared Difference-Nanospectroscopy of the Proton Pump Activity of Bacteriorhodopsin in Single Purple Membrane Patches. Nano Lett. 19(5):3104-3114. doi: 10.1021/acs.nanolett.9b00512. Epub 2019 Apr 17.

 

Böhm M., Boness D., Fantisch E., Erhard, H., Frauenholz J., Kowalzyk Z., Marcinkowski N., Kateriya S., Hegemann P. and Kreimer G. (2019) Phosphorylation of Channelrhodopsin-1 responds to different physiological stimuli and influences the phototactic behavior of Chlamydomonas. Plant Cell 31(4):886-910. doi: 10.1105/tpc.18.00936.

 

Krause, B.S., Kaufmann, J.C.D., Kuhne, J., Vierock, V., Huber, T., Sakmar, T.P., Gerwert, K., Bartl, F.J., and Hegemann, P. (2019) Tracking pore hydration in channelrhodopsin by site-directed infrared-active azido probes. Biochemistry 58(9): 1275-1286. doi: 10.1021/acs.biochem.8b01211.

 

Jens Kuhne*, Johannes Vierock*, Stefan Tennigkeit, Jonas Wietek, Dennis Petersen, Max-Aylmer Dreier, Jonas Schartner, Konstantin Gavrilijuk, Samir F. El-Mashtoly, Peter Hegemann and Klaus Gerwert. (2019) A unifiying photocycle model unraveling light adaptation and temporal evolution of cation conductance in Channelrhodopsin-2 Proc Natl Acad Sci USA. 116(19):9380-9389. doi: 10.1073/pnas.1818707116.

 

Vogt, A., Silapetere, A., Grimm, C., Heiser, F., Möller, M.A. and Hege­mann, P. (2019) Engineered Passive Potassium Conductance in the KR2 Sodium Pump. Biophys. J. 116, 1941-1951. doi.org/10.1016/j.bpj.2019.04.001

 

Mukherjee S, Hegemann P, Broser M. (2019) Enzymerhodopsins: novel photoregulated catalysts for optogenetics. Curr Opin Struct Biol. 2019 Apr 4;57:118-126. doi: 10.1016/j.sbi.2019.02.003. [Epub ahead of print] Review. PMID: 30954887

 

Photoreactions of the Histidine Kinase Rhodopsin Ot-HKR from the Marine Picoalga Ostreococcus tauri. Luck M, Velázquez Escobar F, Glass K, Sabotke MI, Hagedorn R, Corellou F, Siebert F, Hildebrandt P, Hegemann P. Biochemistry. 2019 Apr 9;58(14):1878-1891. doi: 10.1021/acs.biochem.8b01200. Epub 2019 Mar 21. PMID: 30768260

 

Fudim R., Szczepek M., Vierock J., Vogt A., Schmidt A., Kleinau G., Fischer P., Bartl FJ, Scheerer P., and Hegemann P. (2019) Design of a light-gated proton channel based on the high-resolution structure of Coccomyxa rhodopsin Sci. Signal. 12, eaav4203; doi: 10.1126/scisignal.aav4203

 

 

 

2018

Penzkofer A, Hegemann P, Kateriya S (2018) Organic dyes in optogenetics Organic Lasers and Organic Photonics. Edited by F J Duarte. Bristol: IOP Publishing.  pp 13, 1-114

https://iopscience.iop.org/book/978-0-7503-1572-2.pdf

 

Bernal Sierra, Y.A.*, Rost, B.R.*, Pofahl, M.*, Fernandes, A.M., Kopton, R.A., Moser, S., Holtkamp, D., Masala, N., Beed, P., Tukker, J.J., et al. (2018). Potassium channel-based optogenetic silencing. Nature Communications 9, 4611. *equal contribution

https://www.nature.com/articles/s41467-018-07038-8

 

Oda, K., Vierock, J., Oishi, S., Rodriguez-Rozada, S., Taniguchi, R., Yamashita, K., Wiegert, J.S., Nishizawa, T., Hegemann, P., Nureki, O. (2018) Crystal structure of the red light-activated channelrhodopsin Chrimson. Nature Comm. 9(1):3949. doi: 10.1038/s41467-018-06421-9.

https://www.nature.com/articles/s41467-018-06421-9

 

Scheib, U., Broser, M., Constantin, O.M., Yang, S., Gao, S., Mukherjee, S., Stehfest, K., Nagel, G., Gee, C.E., Hegemann, P. (2018) Rhodopsin-cyclases for light-induced cGMP & cAMP production and 2.3 Å structure of an adenylyl cyclase domain. Nature Comm. 9(1):2046. doi: 10.1038/s41467-018-04428-w.

https://www.nature.com/articles/s41467-018-04428-w

 

Grimm, C., Silapetere, A., Vogt, A., Bernal Sierra, Y.A., Hegemann, P. (2018) Electrical properties, ion selectivity and optogenetic potential of an engineered light-driven sodium pump eKR2. Sci Rep. 8:9316. doi: 10.1038/ s41598-018-27690-w.

https://www.nature.com/articles/s41598-018-27690-w

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1982 - 1995