Systems Biology Tools Development For Cell Therapy And Drug Development
SYSTHER is a virtual institute consisting of partners from Germany and Slovenia. It was established to investigate and improve solid tumor treatment based on systems biology approaches. Identification of target genes and proteins, and subsequent mathematical modeling of candidate pathways, intracellular networks and interaction dynamics of immunocompetent, tumor, and stem cell aim at elucidating mechanisms of tumor immunomodulation and the role of tumor stem cells in solid, non-metastasizing tumors, improving thus therapeutic strategies. Serum antibody profiling and gene expression analysis of tumor and stem cells shall further lead to the understanding of immunolodulation mechanisms.