Humboldt-Universität zu Berlin - Structural Biology / Biochemistry

Humboldt-Universität zu Berlin | Department of Biology | Structural Biology / Biochemistry | Research highlights - Group | A new role for Ni in CO2 activation (Nature Catalysis, August 2025)

A new role for Ni in CO2 activation (Nature Catalysis, August 2025)



Yudhajeet Basak, Jae-Hun Jeoung, and Holger Dobbek, together with Christian Lorent and Ingo Zebger (TU Berlin)(UniSysCat), demonstrated that the nickel ion in the active site of carbon monoxide dehydrogenase (Ni,Fe-CODH) is the key player in CO2 activation and conversion. Using a combination of X-ray diffractionand spectroscopy on CODH crystals, they succeeded for the first time in visualizing all catalytically relevant states with bound reaction partners in the enzyme at atomic resolution.

 

Yudhajeet Basak, Christian Lorent et al (2025) Nature Catalysis DOI:10.1038/s41929-025-01388-5