Humboldt-Universität zu Berlin - Structural Biology / Biochemistry

Humboldt-Universität zu Berlin | Department of Biology | Structural Biology / Biochemistry | A catalytic active Michaelis-complex shows its secrets

A catalytic active Michaelis-complex shows its secrets



Our latest paper in Nature Communications describes how only authentic Michaelis complexes display a strong donor–acceptor complex between reduced flavin and substrate. This interaction likely activates the catalytic ground state of the reduced flavin, accelerating the reaction within a compressed cofactor–substrate complex.

http://www.nature.com/articles/ncomms16084

csm 17 07 17 Hildebrandt Fig 3a ncomms16084 f3 a2c1ea0348