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Humboldt-Universitaet zu Berlin - Structural Biology / Biochemistry

Structural Biology and Biochemistry of Metalloenzymes


Research focus: Bateria and Archaea have the ability to use carbon monoxide (CO), carbon dioxide (CO2) and numerous pollutants as carbon and/or energy sources. In order to activate and convert these inert compounds, the organisms use complex metalloenzymes that catalyse reactions under mild cellular conditions. For comparison, in a chemistry laboratory, similar reactions are only possible with valuable catalysators under high pressure and temperatures. How the metal-containing enzymes achieve this feast is hardly understood. 
We use protein crystallography in combination with protein chemistry and  molecular biology to study molecular energy conversions.
Our short term goals are to better understand the molecular bases of catalytic processes and enzyme natural evolution. Our long term goal is to evolve new (bio)catalysators for energy-efficient use of CO2 and CO, as well as for the (bio)degradation of pollutants.
Research areas:

Humboldt-Universität zu Berlin
Lebenswissenschaftliche Fakultät, Institut für Biologie
Prof. Dr. Holger Dobbek
Philippstr. 13, Leonor Michaelis Haus
10115 Berlin


Tel: ++49 30 2093 6369