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Humboldt-Universitaet zu Berlin - Structural Biology / Biochemistry

Publications

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2019

Carbon Monoxide Dehydrogenases
Jeoung, JH, Martins, BM, and Dobbek, H
Methods Mol Bio, 1876:37-54.
Site-Resolved Observation of Vibrational Energy Transfer Using a Genetically Encoded Ultrafast Heater
Baumann, T, Hauf, M, Schildhauer, F, Eberl, KB, Durkin, PM, Deniz, E, Löffler, JG, Acevedo-Rocha, CG, Jaric, J, Martins, BM, Dobbek, H, Bredenbeck, J, and Budisa, N
Angew Chem Int Ed Engl, 58(9):2899-2903.
X-Ray Crystallography of Carbon Monoxide Dehydrogenases
Jeoung, JH, Martins, BM, and Dobbek, H
Methods Mol Biol, 1876:167-178.

2018

ATP-dependent substrate reduction at an [Fe8S9] double-cubane cluster
Jeoung, JH and Dobbek, H
PNAS, 115(12):2994-2999.
Function and crystal structure of the dimeric P-loop ATPase CFD1 coordinating an exposed [4Fe-4S] cluster for transfer to apoproteins
Stehling, O, Jeoung, JH, Freibert, SA, Paul, VD, Bänfer, S, Niggemeyer, B, Rösser, R, Dobbek, H, and Lill, R
PNAS, 115(39):E9085-E9094.
Improving the accuracy and resolution of neutron crystallographic data by three-dimensional profile fitting of Bragg peaks in reciprocal space
Sullivan, B, Archibald, R, Langan, PS, Dobbek, H, Bommer, M, McFeeters, RL, Coates, L, Wang, X, Gallmeier, F, Carpenter, JM, Lynch, V, and Langan, P
Acta Crystallogr S Struct Biol, D74:1085-1095.
Optimizing Crystal Size of Photosystem II by Macroseeding: Toward Neutron Protein Crystallography
Hussein, R, Ibrahim, M, Chatterjee, R, Coates, L, Müh, F, Yachandra, VK, Yano, J, Kern, J, Dobbek, H, and Zouni, A
Cryst Growth Des, 18(1):85-94.
Selective utilization of benzimidazolyl-norcobamides as cofactors by the tetrachloroethene reductive dehalogenase of Sulfurospirillum multivorans
Keller, S, Kunze, C, Bommer, M, Paetz, C, Menezes, RC, Svatoš, A, Dobbek, H, and Schubert, T
J Bacteriol, 200(8):e00584-17.
Structural basis for prolidase deficiency disease mechanisms
Wilk, P, Uehlein, M, Piwowarczyk, R, Dobbek, H, Mueller, U, and Weiss, MS
FEBS J, 285(18):3422-3441.
Structures of the intermediates of Kok's photosynthetic water oxidation clock
Kern, J, Chatterjee, R, Young, ID, Fuller, FD, Lassalle, L, Ibrahim, M, Gul, S, Fransson, T, Brewster, AS, Alonso-Mori, R, Hussein, R, Zhang, M, Douthit, L, de Lichtenberg, C, Cheah, MH, Shevela, D, Wersig, J, Seuffert, I, Sokaras, D, Pastor, E, Weninger, C, Kroll, T, Sierra, RG, Aller, P, Butryn, A, Orville, AM, Liang, M, Batyuk, A, Koglin, JE, Carbajo, S, Boutet, S, Moriarty, NW, Holton, JM, Dobbek, H, Adams, PD, Bergmann, U, Sauter, NK, Zouni, A, Messinger, J, Yano, J, and Yachandra, VK
Nature, 563(7731):421-425.

2017

CO Dehydrogenase and Acetyl-CoA Synthase Assembly
Dobbek, H
edited by Robert A. Scott. John Wiley & Sons, Ltd: Chichester, UK.
CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2.
Domnik, L, Merrouch, M, Goetzl, S, Jeoung, JH, Léger, C, Dementin, S, Fourmond, V, and Dobbek, H
Angew Chem Int Ed Engl., 56:15466-15469.
Carbon Monoxide Dehydrogenase Reduces Cyanate to Cyanide
Ciaccafava, A, Tombolelli, D, Domnik, L, Jeoung, JH, Dobbek, H, Mroginski, MA, Zebger, I, and Hildebrandt, P
Angewandte Chemie, 56:7398-7401.
Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer
Kunze, C, Bommer, M, Hagen, W, Uksa, M, Dobbek, H, Schubert, T, and Diekert, G
Nature Communications, 8:ncomms15858.
Inducer exclusion in Firmicutes: insights into the regulation of a carbohydrate ATP binding cassette transporter from Lactobacillus casei BL23 by the signal transducing protein P-Ser46-HPr
Homburg, C, Bommer, M, Wuttge, S, Hobe, C, Beck, S, Dobbek, H, Deutscher, J, Licht, A, and Schneider, E
Molecular Microbiology, 105:25-45.
Ligand binding at the A-cluster in full-length or truncated acetyl-CoA synthase studied by X-ray absorption spectroscopy
Schrapers, P, Ilina, J, Gregg, CM, Mebs, S, Jeoung, JH, Dau, H, Dobbek, H, and Haumann, M
PLOS ONE, 12:e0171039.
NITROGENASE A fuel-producing microbe
Dobbek, H
Nature Chemical Biology, 13:134-135.
Photoactivatable Mussel-Based Underwater Adhesive Proteins by an Expanded Genetic Code
Hauf, M, Richter, F, Schneider, T, Faidt, T, Martins, BM, Baumann, T, Durkin, P, Dobbek, H, Jacobs, K, Moeglich, A, and Budisa, N
ChemBioChem, 18:1-6.
Playing marble run to make methane
Dobbek, H
Science, 357(6352):642-643.
Protein crystallization and initial neutron diffraction studies of the photosystem II subunit PsbO
Bommer, M, Coates, L, Dau, H, Zouni, A, and Dobbek, H
Acta Crystallogr F Struct Biol Commun, 73:525-531.
Protein dynamics in the reductive activation of a B12-containing enzyme
Götzl, S, Teutloff, C, Werther, T, Hennig, SE, Jeoung, JH, Bittl, R, and Dobbek, H
Biochemistry, Epub ahead of print.
Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase
Werther, T, Wahlfeld, S, Salewski, J, Kuhlmann, U, Zebger, I, Hildebrandt, P, and Dobbek, H
Nature Communications, 8:ncomms16084.
Structural insights into the light-driven auto-assembly process of the water oxidizing Mn4CaO5-cluster in photosystem II
Zhang, M, Bommer, M, Chatterjee, R, Hussein, R, Yano, J, Dau, H, Kern, J, Dobbek, H, and Zouni, A
eLIFE, 6:e21347.
Substrate specificity and reaction mechanism of human prolidase
Wilk, P, Uehlein, M, Kalms, J, Dobbek, H, Mueller, U, and Weiss, M
The FEBS Journal, 284(17):2870-2885.
Switchable Redox Chemistry of the Hexameric Tyrosine-Coordinated Heme Protein
Kielb, P, Utesch, T, Kozuch, J, Jeoung, J, Dobbek, H, Mroginski, M, Hildebrandt, P, and Weidinger, I
Journal of Physical Chemistry B, 121:3955-3964.

2016

AcsF Catalyzes the ATP-dependent Insertion of Nickel into the Ni,Ni-[4Fe4S] Cluster of Acetyl-CoA Synthase
Gregg, C, Goetzl, S, Jeoung, J, and Dobbek, H
The Journal of Biological Chemistry, 291:18129-18138.
Anaerobic Microbial Degradation of Hydrocarbons: From Enyzmatic Reactions to the Environment
Rabus, R, Boll, M, Heider, J, Meckenstock, RU, Buckel, W, Einsle, O, Erlmer, U, Golding, BT, Gunsalus, RP, Kroneck, PM, Krüger, M, Lueders, T, Martins, BM, Musat, F, Richnow, HH, Schink, B, Seifert, J, Szaleniec, M, Treude, T, Ullmann, GM, Vogt, C, von Bergen, M, and Wilkes, H
J Mol Microbiol Biotechnol, 26(1-3):5-28.
Axial Ligation and Redox Changes at the Cobalt Ion in Cobalamin Bound to Corrinoid Iron-Sulfur Protein (CoFeSP) or in Solution Characterized by XAS and DFT
Schrapers, P, Mebs, S, Goetzl, S, Hennig, S, Dau, H, Dobbek, H, and Haumann, M
PLOS ONE, 11:e0158681.
Crystallographic and Computational Analysis of the Barrel Part of the PsbO Protein of Photosystem II: Carboxylate-Water Clusters as Putative Proton Transfer Relays and Structural Switches
Bommer, M, Bondar, A, Zouni, A, Dobbek, H, and Dau, H
Biochemistry, 55:4626-4635.
Fermentative Cyclohexane Carboxylate Formation in Synthrophus aciditrophicus
Boll, M, Kung, JW, Ermler, U, Martins, BM, and Buckel, W
J Mol Microbiol biotechnol, 26(1-3):165-179.
Insights into Reductive Dehalogenase Function Obtained from Crystal Structures
Dobbek, H and Leys, D
Springer, Editors L Adrian, F Löffler, Berlin, Heidelberg. (ISBN: 978-3-662-49875-0).
Molecularly Imprinted Electropolymer for a Hexameric Heme Protein with Direct Electron Transfer and Peroxide Electrocatalysis
Peng, L, Yarman, A, Jetzschmann, K, Jeoung, J, Schad, D, Dobbek, H, Wollenberger, U, and Scheller, F
Sensors, 16:s16030272.
Quercetin 2,4-Dioxygenase Activates Dioxygen in a Side-On O2 -Ni Complex
Jeoung, J, Nianios, D, Fetzner, S, and Dobbek, H
Angew Chem In Ed Engl [Epub].
Structure and Function of 4-Hydroxylphenylacetate Decarboxylase and Its Cognate Activating Enzyme
Selvaraj, B, Buckel, W, Golding, BT, Ullmann, GM, and Martins, BM
J Mol Microbiol biotechnol, 26(1-3):76-91.
Structure and Function of Benzylsuccinate Synthase and Related Furamate-Adding Glycyl Radical Enzymes
Heider, J, Szaleniec, M, Martins, BM, Seyhan, D, Buckel, W, and Golding, BT
J Mol Microbiol Biotechnol, 26(1-3):29-44.
Structure of an Actinobacterial-Type [NiFe]-Hydrogenase Reveals Insight into O2-Tolerant H2 Oxidation
Schäfer, C, Bommer, M, Hennig, SE, Jeoung, J, Dobbek, H, and Lenz, O
Structure , 24:285-92.
Structure of photosystem II and substrate binding at room temperature
Young, I, Ibrahim, M, Chatterjee, R, Gul, S, Fuller, F, Koroidov, S, Brewster, A, Tran, R, Alonso-Mori, R, Kroll, T, Michels-Clark, T, Laksmono, H, Sierra, R, Stan, C, Hussein, R, Zhang, M, Douthit, L, Kubin, M, de Lichtenberg, C, Pham, L, Nilsson, H, Cheah, M, Schevela, D, Saracini, C, Bean, M, Seuffert, I, Sokaras, D, Weng, T, Pastor, E, Weninger, C, Fransson, T, Lassalle, L, Braeuer, P, Aller, P, Docker, P, Andi, B, Orville, A, Glownia, J, Nelson, S, Sikorski, M, Zhu, D, Hunter, M, Lane, T, Aquila, A, Koglin, J, Robinson, J, Liang, M, Boutet, S, Lyubimov, A, Uervironjnankoorn, M, Moriarty, N, Evans, G, Wernet, P, Dobbek, H, Weis, W, Brunger, A, Zwart, P, Adams, P, Zouni, A, Messinger, J, Bergmann, U, Sauter, N, Kern, J, Yachandra, V, and Yano, J
Nature, 540:453-457.
The binuclear nickel center in the A-cluster of acetyl-CoA synthase (ACS) and two biomimetic dinickel complexes studied by X-ray absorption and emission spectroscopy
Schrapers, P, Mebs, S, Ilina, Y, Warner, D, Woermann, C, Schuth, N, Kositzki, R, Dau, H, Limberg, C, and Dobbek, H
Journal of Physics Conference Series, 712:012029.
When the inhibitor tells more than the substrate: the cyanide-bound state of a carbon monoxide dehydrogenase
Ciaccafava, A, Tombolelli, D, Domnik, L, Fesseler, J, Jeoung, J, Dobbek, H, Mroginski, M, Zebger, I, and Hildebrandt, P
Chemical Science, 7:3162-3171.

2015

Direct Electron Transfer and Bioelectrocatalysis by a Hexameric, Heme Protein at Nanostructured Electrodes
Tanne, J, Jeoung, J, Peng, L, Yarman, A, Dietzel, B, Schulz, B, Schad, D, Dobbek, H, Wollenberger, U, Bier, FF, and Scheller, FW
Electroanalysis, 27(10):2262-2267.
How the [NiFe4S4] Cluster of CO Dehydrogenase Activates CO2 and NCO(-)
Fesseler, J, Jeoung, J, and Dobbek, H
Angew Chem Int Ed Engl., 54(29):8560-4.
O2 Inhibition of Ni-Containing CO Dehydrogenase Is Partly Reversible
Merrouch, M, Hadj-Said, J, Domnik, L, Dobbek, H, Leger, C, Dementin, S, and Fourmond, V
Chemistry, 21(52):18934-18938.
Substrate-induced radical formation in 4-hydroxybutyryl coenzyme A dehydratase from Clostridium aminobutyricum
Zhang, J, P, F, Pierik, AJ, Martins, BM, and Buckel, W
Appl Environ Microbiol, 81(3):1071-84.
Surface-Tuned Electron Transfer and Electrocatalysis of Hexameric Tyrosine-Coordinated Heme Protein (HTHP).
Peng, L, Utesch, T, Yarman, A, Jeoung, JH, Steinborn, S, Dobbek, H, Mroginski, MA, Tanne, J, Wollenberger, U, and Scheller, FW
Chemistry, 21(20):7596-7602.

2014

ATP-induced electron transfer by redox-selective partner recognition
Hennig, S, Goetzl, S, Jeoung, JH, Bommer, M, Lendzian, F, Hildebrandt, P, and Dobbek, H
Nature Communications, 5(4626).
Carbon monoxide. toxic gas and fuel for anaerobes and aerobes: carbon monoxide dehydrogenases
Jeoung, JH, Fesseler, J, Goetzl, S, and Dobbek, H
Met Ions Life Sci, 14:37-69.
Native-like Photosystem II Superstructure at 2.44 A Resolution through Detergent Extraction from the Protein Crystal
Hellmich, J, Bommer, M, Burkhardt, A, Ibrahim, M, Kern, J, Meents, A, Müh, F, Dobbek, H, and Zouni, A
Structure, 22:1607-1615.
Structural basis for organohalide respiration
Bommer, M, Kunze, C, J, F, Schubert, T, Diekert, G, and Dobbek, H
Science, 346:455-8.
The extended reductive acetyl-CoA pathway: ATPases in metal cluster maturation and reductive activation
Jeoung, JH, Goetzl, S, Hennig, S, Fesseler, J, Wörmann, C, Dendra, J, and Dobbek, H
Biological Chemistry, 395(5):545-548.
The ferredoxin-like domain of the activating enzyme is required for generating a lasting glycyl radical in 4-hydroxyphenylacetate decarboxylase
Selvaraj, B, Pierik, AJ, Bill, E, and Martins, BM
J Biol Inorg Chem, 19:1317-26.

2013

4-Hydroxyphenylacetate decarboxylase activating enzyme catalyses a classical S-adenosylmethionine reductive cleavage reaction
Selvaraj, B, Pierik, AJ, Bill, E, and Martins, BM
Journal of Biological Inorganic Chemistry, 18:633-643.
Catalytic Mechanism of the Glycyl Radical Enzyme 4-Hydroxyphenylacetate Decarboxylase from Continuum Electrostatic and QC/MM Calculations
Feliks, M, Martins, BM, and Ullmann, GM
JACS, 135:14574-14585.
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO2 Fixation
Apple, A, JE, B, AB, B, Dobbek, H, Dubois, D, Dupuis, M, Ferry, J, Fujita, E, Hille, R, Kenis, P, Kerfeld, C, Morris, R, Peden, C, Portis, A, Ragsdale, S, Rauchfuss, T, Reek, J, Seefeldt, L, Thauer, R, and Waldrop, G
Chem Rev., 113(8):6621-58.
Visualizing the substrate-, superoxo-, alkylperoxo-, and product-bound states at the nonheme Fe(II) site of homogentisate dioxygenase
Jeoung, JH, Bommer, M, Lin, TY, and Dobbek, H
Proc Natl Acad Sci U S A, 110:12625-30.
Zero-field splittings in metHb and metMb with aquo and fluoro ligands: a FD-FT THz-EPR study
Nehrkorn, J, Martins, BM, Holldack, K, Stoll, S, Dobbek, H, Bittl, R, and Schnegg, A
Mol Phys, 111:2696-2707.

2012

Complex formation with the activator RACo affects the corrinoid structure of CoFeSP
Meister, W, Hennig, SE, Jeoung, J, Lendzian, F, Dobbek, H, and Hildebrandt, P
Biochemistry, 51(36):7040-7042.
Determinants of substrate specificity and biochemical properties of the sn-glycerol-3-phosphate ATP binding casette transporter [UgpB-AEC2] of Escherichia coli
Wuttge, S, Bommer, M, Jäger, F, Martins, B, Jacob, S, Licht, A, Scheffel, F, Dobbek, H, and Schneider, E
Mol. Microbiol., 86:908-920.
Determinants of substrate specificity and biochemical properties of the sn-glycerol-3-phosphate ATP binding cassette transporter (UgpB-AEC2 ) of Escherichia coli
Wuttge, S, Bommer, M, Jäger, F, Martins, BM, Jacob, S, Licht, A, Scheffel, F, Dobbek, H, and Schneider, E
Mol. Microbiol., 86:908-20.
Enzyme catalyzed radical dehydrations of hydroxy acids
Buckel, W, Zhang, J, Friedrich, P, Parthasarathy, A, Li, H, Djurdjevic, I, Dobbek, H, and Martins, BM
Biochimica et Biophysica Acta, 1824(11):1278-1290.
Enzyme catalyzed radical dehydrations of hydroxy acids
Buckel, W, Zhang, J, Friedrich, P, Parthasarathy, A, Li, H, Djurdjevic, I, Dobbek, H, and Martins, BM
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1824:1278-1290.
On the ATP-dependent activation of the radical enzyme (R)-2-hydroxyisocaproyl-CoA dehydratase
Knauer, SH, Buckel, W, and Dobbek, H
Biochemistry, 51:6609-22.
Redox-dependent complex formation by an ATP-dependent activator of the corrinoid/iron-sulfur protein
Hennig, S, Jeoung, J, Goetzl, S, and Dobbek, H
Proceedings of the National Academy of Sciences USA, 109(14):5235-5240.
Structural and energetic basis of infection by the filamentous bacteriophage IKe
Roman, J, Geitner, A, Weininger, U, Balbach, J, Dobbek, H, and Schmid, FX
Molecular Microbiology, 84(6):1124-1138.
Structural and energetic basis of infection by the filamentous bacteriophage IKe.
Jakob, RP, Geitner, AJ, Weininger, U, Balbach, J, Dobbek, H, and Schmid, FX
Molecular Microbiology, 84(6):1124-1138.
Suppression of electron transfer to dioxygen by charge transfer and electron transfer complexes in the FAD-dependent reductase component of toluene dioxygenase
Lin, T, Werther, T, Jeoung, J, and Dobbek, H
J. Biol Chem., 287:38338-46.
The Fe(II) /α-ketoglutarate dependent taurine dioxygenases from Pseudomonas putida and Escherichia coli are tetramers
Knauer, S, Hartl-Spiegelhauer, O, Schwarzinger, S, Haenzelmann, P, and Dobbek, H
FEBS Journal, 279(5):816-831.
n-Butyl isocyanide oxidation at the [NiFe4S4OHx] cluster of CO dehydrogenase
Jeoung, J and Dobbek, H
Journal of Biological Inorganic Chemistry, 17(2):167-173.

2011

Structural Basis for Electron and Methyl-Group Transfer in a Methyltransferase System Operating in the Reductive Acetyl-CoA Pathway
Goetzl, S, Jeoung, J, Hennig, S, and Dobbek, H
Journal of Molecular Biology, 411(1):96-109.
Structural Basis for Reductive Radical Formation and Electron Recycling in (R)-2-Hydroxyisocaproyl-CoA Dehydratase
Knauer, SH, Buckel, W, and Dobbek, H
Journal of the American Chemical Society, 133(12):4342-4347.
Structural Basis for a Kolbe-Type Decarboxylation Catalyzed by a Glycyl Radical Enzyme
Martins, BM, Blaser, M, Feliks, M, Ullmann, GM, Buckel, W, and Selmer, T
Jounal of the American Chemical Society, 133(37):14666-74.
Structural aspects of mononuclear Mo/W-enzymes
Dobbek, H
Coordination Chemistry Reviews, 255:1104-1116.
The filamentous phages fd and IF1 use different mechanisms to infect Escherichia coli
Lorenz, SH, Jakob, RP, Weininger, U, Balbach, J, Dobbek, H, and Schmid, FX
Journal of Molecular Biology, 405(4):989–1003.

2010

Crystal structure of the ATP-dependent maturation factor of Ni,Fe-containing carbon monoxide dehydrogenases
Jeoung, J, Giese, T, Gruenwald, M, and Dobbek, H
Journal of Molecular Biology, 396(4):1165–1179.
Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface
Wenzel, S, Martins, BM, Rösch, P, and Wöhrl, B
Biochem. J., 425(2):373-380.
Cysteine as a modulator residue in the active site of xenobiotic reductase A: a structural, thermodynamic and kinetic study
Spiegelhauer, O, Mende, S, Dickert, F, Knauer, SH, Ullmann, GM, and Dobbek, H
Journal of Molecular Biology, 398(1):66–82.
Determinants of substrate binding and protonation in the flavoenzyme xenobiotic reductase A
Spiegelhauer, O, Werther, T, Mende, S, Knauer, SH, and Dobbek, H
Journal of Molecular Biology, 403(2):286–298.
Elimination of a cis-proline-containing loop and turn optimization stabilizes a protein and accelerates its folding
Jakob, RP, Zierer, BK, Weininger, U, Hofmann, SD, Lorenz, SH, Balbach, J, Dobbek, H, and Schmid, FX
Journal of Molecular Biology, 399(4):331–346.

2009

CooC1 from Carboxydothermus hydrogenoformans is a nickel-binding ATPase
Jeoung, J, Giese, T, Gruenwald, M, and Dobbek, H
Biochemistry, 48(48):11505–11513.
Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface
Wenzel, S, Martins, BM, Roesch, P, and Woehrl, BM
Biochemical Journal, 425(2):373-380.
Kinetic characterization of xenobiotic reductase A from Pseudomonas putida 86
Spiegelhauer, O, Dickert, F, Mende, S, Niks, D, Hille, R, Ullmann, GM, and Dobbek, H
Biochemistry, 48(48):11412–11420.
Structural basis of cyanide inhibition of Ni, Fe-containing carbon monoxide dehydrogenase
Jeoung, J and Dobbek, H
Journal of the American Chemical Society, 131(29):9922–9923.
The Mo-Se active site of nicotinate dehydrogenase
Wagener, N, Pierik, AJ, Ibdah, A, Hille, R, and Dobbek, H
Proceedings of the National Academy of Sciences US, 106(27):11055–11060.

2008

Bioinorganic chemistry - How biological Fe-S-Centre activates CO2
Dobbek, H
Nachrichten aus der Chemie, 56:734-737.
Changing the determinants of protein stability from covalent to non-covalent interactions by in vitro evolution: a structural and energetic analysis
Kather, I, Jakob, R, Dobbek, H, and Schmid, FX
Journal of Molecular Biology, 381(4):1040–1054.
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
Kather, I, Jakob, RP, Dobbek, H, and Schmid, FX
Journal of Molecular Biology, 383(1):238–251.

2007

Assignment of individual metal redox states in a metalloprotein by crystallographic refinement at multiple X-ray wavelengths
Einsle, O, Andrade, SL, Dobbek, H, Meyer, J, and Rees, DC
Journal of the American Chemical Society, 129(8):2210–2211.
Carbon dioxide activation at the Ni,Fe-cluster of anaerobic carbon monoxide dehydrogenase
Jeoung, J and Dobbek, H
Science, 318(5855):1461–1464.
HTHP: a novel class of hexameric, tyrosine-coordinated heme proteins
Jeoung, J, Pippig, DA, Martins, BM, Wagener, N, and Dobbek, H
Journal of Molecular Biology, 368(4):1122–1131.
Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies
Zoldak, G, Redecke, L, Svergun, DI, Konarev, PV, Voertler, CS, Dobbek, H, Sedlak, E, and Sprinzl, M
Nucleic Acids Research, 35(4):1343–1353.

2006

Basic requirements for a metal-binding site in a protein: the influence of loop shortening on the cupredoxin azurin
Li, C, Yanagisawa, S, Martins, BM, Messerschmidt, A, Banfield, M, and Dennison, C
Proceedings of the National Academy of Science USA, 103(19):7258-63.
Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis
Svetlitchnaia, T, Svetlitchnyi, V, Meyer, O, and Dobbek, H
Proceedings of the National Academy of Sciences US, 103(39):14331-14336.
Xenobiotic reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction
Griese, J, Jakob, R, Schwarzinger, S, and Dobbek, H
Journal of Molecular Biology, 361(1):140–152.

2005

2-Oxoquinoline 8-monooxygenase oxygenase component: active site modulation by Rieske-[2Fe-2S] center oxidation/reduction
Martins, B, Svetlitchnaia, T, and Dobbek, H
Structure, 13(5):817–824.
Radical-mediated dehydration reactions in anaerobic bacteria
Buckel, W, Martins, BM, Messerschmidt, A, and Golding, BT
Biological Chemistry, 386(10):951-9.
Structural and functional reconstruction in situ of the [CuSMoO2] active site of carbon monoxide dehydrogenase from the carbon monoxide oxidizing eubacterium Oligotropha carboxidovorans
Resch, M, Dobbek, H, and Meyer, O
Journal of Biological Inorganic Chemistry, 10(5):518–528.
Structural basis for stereo-specific catalysis in NAD(+)-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans
Martins, BM, Macedo-Ribeiro, S, Bresser, J, Buckel, W, and Messerschmidt, A
FEBS Journal, 272(1):269-81.

2004

A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans
Svetlitchnyi, V, Dobbek, H, Meyer-Klaucke, W, Meins, T, Thiele, B, Roemer, P, Huber, R, and Meyer, O
Proceedings of the National Academy of Sciences US, 101(2):446–451.
Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase
Bonin, I, Martins, BM, Puranov, V, Fetzner, S, Huber, R, and Dobbek, H
Structure, 12(8):1425–1435.
Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase
Bonin, I, Martins, BM, Purvanov, V, Fetzner, S, Huber, R, and Dobbek, H
Structure, 12(8):1425-35.
Carbon monoxide induced decomposition of the active site [Ni-4Fe-5S] cluster of CO dehydrogenase
Dobbek, H, Svetlitchnyi, V, Liss, J, and Meyer, O
Journal of the American Chemical Society, 126(17):5382–5387.
Crystal structure of 4-hydroxybutyryl-CoA dehydratase: radical catalysis involving a [4Fe-4S] cluster and flavin
Martins, BM, Dobbek, H, Cinkaya, I, Buckel, W, and Messerschmidt, A
Proceedings of the National Academy of Sciences US, 101(44):15645–15649.

2003

Oxygen-dependent coproporphyrinogen-III oxidase from Escherichia coli: one-step purification and biochemical characterisation.
Macieira, S, Martins, BM, and Huber, R
FEMS Microbiology Letters, 226(1):31-7.

2002

7
Dobbek, H and Huber, R
In: Metal Ions in Biological Systems, ed. by Siegel. Marcel Dekker, chap. 7, pp. 227–263.
Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution
Dobbek, H, Gremer, L, Kiefersauer, R, Huber, R, and Meyer, O
Proceedings of the National Academy of Sciences US, 99(25):15971–15976.

2001

Crystal structure and substrate binding modeling of the uroporphyrinogen-III decarboxylase from Nicotiana tabacum. Implications for the catalytic mechanism.
Martins, BM, Grimm, B, Mock, H, Huber, R, and Messerschmidt, A
Journal of Biological Chemistry, 276(47):44108-16.
Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster
Dobbek, H, Svetlitchnyi, V, Gremer, L, Huber, R, and Meyer, O
Science, 293(5533):1281–1285.
New insights into the thermostability of bacterial ferredoxins: high-resolution crystal structure of the seven-iron ferredoxin from Thermus thermophilus.
Macedo-Ribeiro, S, Martins, BM, Pereira, PJ, Buse, G, Huber, R, and Soulimane, T
Journal of Biological Inorganic Chemistry, 6(7):663-74.
Tobacco uroporphyrinogen-III decarboxylase: characterization, crystallization and preliminary X-ray analysis.
Martins, BM, Grimm, B, Mock, H, Huber, R, and Messerschmidt, A
Acta Crystallographica Section D Biological Crystallography, 57(11):1709-11.

2000

A novel free mounting system for protein crystals: transformation and improvement of diffraction power by accurately controlled humidity changes
Kiefersauer, R, Than, ME, Dobbek, H, Gremer, L, Melero, M, Strobl, S, Dias, J, Soulimane, T, and Huber, R
Journal of Applied Crystallography, 33(5):1223-1230.
Binding of flavin adenine dinucleotide to molybdenum-containing carbon monoxide dehydrogenase from Oligotropha carboxidovorans. Structural and functional analysis of a carbon monoxide dehydrogenase species in which the native flavoprotein has been replace
Gremer, L, Kellner, S, Dobbek, H, Huber, R, and Meyer, O
Journal of Biological Chemistry, 275(3):1864–1872.
The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase
Haenzelmann, P, Dobbek, H, Gremer, L, Huber, R, and Meyer, O
Journal of Molecular Biology, 301(5):1221–1235.
The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase
Meyer, O, Gremer, L, Ferner, R, Ferner, M, Dobbek, H, Gnida, M, Meyer-Klaucke, W, and Huber, R
Biological Chemistry, 381(9-10):865–876.

1999

Crystal structure and mechanism of CO-Dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine
Dobbek, H, Gremer, L, Meyer, O, and Huber, R
Proceedings of the National Academy of Sciences US, 96(16):8884–8889.

1997

Isolation, cloning, sequence analysis and x-ray structure of dimethyl sulfoxide trimethylamine N-oxide reductase from Rhodobacter capsulatu
Knaeblein, J, Dobbek, H, Ehlert, S, and Schneider, F
Biological Chemistry, 378(3-4):293–302.
Organization of the DMSO respiratory operon of Rhodobacter capsulatus and its consequences for homologous expression of DMSOR/TMAOR
Knaeblein, J, Dobbek, H, and Schneider, F
Biological Chemistry, 378(3-4):293–302.