Methods
|
|||
Metabolomics
|
|||
|
|||
Phenotypical Characterization of CellsTo monitor the behaviour of our experimental systems, a broad range of phenotypical parameters is tested for their potential to describe the system. Appropriate markers and assays are selected and constantly measured and applied to characterize the system phenotypically. This includes for instance the characterization of cells based on suitable markers, as well as migration, differentiation and proliferation assays. |
|||
Bioinformatics / Informatics
A tremendeous amount of high-thoughput data representing different data
types is generated in the project. These data needs to be stored,
integrated and analyzed. We developed a database for the storage and
analysis of the SYSTHER data that is accessible for all partners within
the consortium. Gene expression data is analyzed to identify genes that
differentially expressed and pathways that are influenced in the
conditions that are investigated. We apply standard analysis approaches
and develop new algorithms e.g. to integrate data of different sources
and derive biologically meaningful hypotheses out of the
analysis. |
|||
Systems BiologySystems Biology focusses on the systematic study of complex interactions in biological systems. Based on the data generated from our experimental systems, selected parts and modules will be identified that will be studied and described in detail to develop a model. |