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Humboldt-Universität zu Berlin - Mikrobiologie


Svane, S., J.J. Sigurdarson, F. Finkenwirth, T. Eitinger and H. Karring. 2020. Inhibition of urease activity by different compounds provides insight into the modulation and association of bacterial nickel import and ureolysis. Scientific Reports 10:8503.
[Sci. Rep.]


Finkenwirth, F., M. Sippach, S.N. Pecina, M. Gäde, J. Ruta, A. Ricke, E. Bondarenko, J.P. Klare, M. Zinke, S. Lange, A. Lange, H.-J. Steinhoff and T. Eitinger. 2020. Dynamic interactions of CbiN and CbiM trigger activity of a cobalt energy-coupling-factor transporter. Biochimica et Biophysica Acta - Biomembranes 1862:183114.
[Biochim. Biophys. Acta - Biomembranes]


Finkenwirth, F. and T. Eitinger. 2019. ECF-type ABC transporters for uptake of vitamins and transition metal ions into prokaryotic cells. Research in Microbiology 170:358-365.
[Res. Microbiol.]


Finkenwirth, F., F. Kirsch and T. Eitinger. 2017. Complex stability during the transport cycle of a subclass I ECF transporter. Biochemistry 56:4578-4583.


Finkenwirth, F., M. Sippach, H. Landmesser, F. Kirsch, A. Ogienko, M. Grunzel, C. Kiesler, H.-J. Steinhoff, E. Schneider and T. Eitinger. 2015. ATP-dependent conformational changes trigger substrate capture and release by an ECF-type biotin transporter. Journal of Biological Chemistry 290:16929-16942.
[J. Biol. Chem.] [Press Release (in German)]


Kirsch, F. and T. Eitinger. 2014. Transport of nickel and cobalt ions into bacterial cells by S components of ECF transporters. BioMetals 27:653-660.


Yu, Y., M. Zhou, F. Kirsch, C. Xu, L. Zhang, Y. Wang, Z. Jiang, N. Wang, J. Li, T. Eitinger and M. Yang. 2014. Planar substrate binding site dictates the specificity of ECF-type nickel/cobalt transporters. Cell Research 24:267-277.
[Cell Res.]


Finkenwirth, F., F. Kirsch and T. Eitinger. 2014. A versatile Escherichia coli strain for identification of biotin transporters and for biotin quantification. Bioengineered 5:129-132.


Finkenwirth, F., F. Kirsch and T. Eitinger. 2013. Solitary BioY proteins mediate biotin transport into recombinant Escherichia coli. Journal of Bacteriology 195:4105-4111.
[J. Bacteriol.]


Eitinger, T. 2013. Transport of nickel and cobalt in prokaryotes. In Metals and Cells (Encyclopedia of Inorganic and Bioinorganic Chemistry series) (Culotta, V. and Scott, R.A., Eds.), pp. 145-154, John Wiley & Sons, Chichester, UK.


Eitinger, T. 2013. Cobalt transporters. Chapter 74. In Encyclopedia of Metalloproteins (Kretsinger, R.H., Uversky, V.N. and Permyakov, E.A., Eds.). Springer-Verlag Berlin Heidelberg. DOI: 10.1007/SpringerReference_309393 2012-02-23 14:50:27 UTC .


Eitinger, T. 2013. Nickel transporters. Chapter 85. In Encyclopedia of Metalloproteins (Kretsinger, R.H., Uversky, V.N. and Permyakov, E.A., Eds.). Springer-Verlag Berlin Heidelberg. DOI: 10.1007/SpringerReference_307412 2012-02-06 10:48:53 UTC.


Ziomkowska, J., F. Kirsch, A. Herrmann and T. Eitinger. 2012. FRET in lebenden Bakterien. Analyse eines unkonventionellen Vitamin-Transporters. BIOspektrum 18:493-496.


Kirsch, F., S. Frielingsdorf, A. Pohlmann, J. Ziomkowska, A. Herrmann and T. Eitinger. 2012. Essential amino acid residues of BioY reveal that dimers are the functional S unit of the Rhodobacter capsulatus biotin transporter. Journal of Bacteriology 194:4505-4512.
[J. Bacteriol.]


Neubauer, O., C. Reiffler, L. Behrendt and T. Eitinger. 2011. Interactions among the A and T units of an ECF-type biotin transporter analyzed by site-specific crosslinking. PLoS ONE 6:e29087.


Eitinger, T., D.A. Rodionov, M. Grote and E. Schneider. 2011. Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions. FEMS Microbiology Reviews 35:3-67.
[FEMS Microbiol. Rev.]


Finkenwirth, F., O. Neubauer, J. Gunzenhäuser, J. Schoknecht, S. Scolari, M. Stöckl, T. Korte, A. Herrmann and T. Eitinger. 2010. Subunit composition of an energy-coupling-factor-type biotin transporter analysed in living bacteria. Biochemical Journal 431:373-380.
[Biochem. J.]


Siche, S., O. Neubauer, P. Hebbeln and T. Eitinger. 2010. A bipartite S unit of an ECF-type cobalt transporter. Research in Microbiology 161:824-829.
[Res. Microbiol.]


Neubauer, O., A. Alfandega, J. Schoknecht, U. Sternberg, A. Pohlmann and T. Eitinger. 2009. Two essential arginine residues in the T components of energy-coupling factor transporters. Journal of Bacteriology 191:6482-6488.
[J. Bacteriol.]


Rodionov, D.A., P. Hebbeln, A. Eudes, J. ter Beek, I.A. Rodionova, G.B. Erkens, D.J. Slotboom, M.S. Gelfand, A.L. Osterman, A.D. Hanson and T. Eitinger. 2009. A novel class of modular transporters for vitamins in prokaryotes. Journal of Bacteriology 191:42-51.
[J. Bacteriol.] [F1000Prime]


Hebbeln, P., D.A. Rodionov, A. Alfandega and T. Eitinger. 2007. Biotin uptake in prokaryotes by solute transporters with an optional ATP-binding cassette-containing module. Proceedings of the National Academy of Sciences of the U.S.A. 104:2909-2914.
[Proc. Natl. Acad. Sci. USA]


Pohlmann, A., W.F. Fricke, F. Reineke, B. Kusian, H. Liesegang, R. Cramm, T. Eitinger, C. Ewering, M. Pötter, E. Schwartz, A. Strittmatter, I. Voß, G. Gottschalk, A. Steinbüchel, B. Friedrich and B. Bowien. 2006. Ralstonia eutropha H16: Genom eines Bioplastik produzierenden Knallgasbakteriums. GenomXPress 4:7-8.


Pohlmann, A., W.F. Fricke, F. Reineke, B. Kusian, H. Liesegang, R. Cramm, T. Eitinger, C. Ewering, M. Pötter, E. Schwartz, A. Strittmatter, I. Voß, G. Gottschalk, A. Steinbüchel, B. Friedrich and B. Bowien. 2006. Genome sequence of the bioplastic-producing "Knallgas" bacterium Ralstonia eutropha H16. Nature Biotechnology 24:1257-1262.
[Nat. Biotechnol.]


Rodionov, D.A., P. Hebbeln, M.S. Gelfand and T. Eitinger. 2006. Comparative and functional genomic analysis of prokaryotic nickel and cobalt uptake transporters: evidence for a novel group of ATP-binding cassette transporters. Journal of Bacteriology 188:317-327.
[J. Bacteriol.


Eitinger, T., J. Suhr, L. Moore and J.A.C. Smith. 2005. Secondary transporters for nickel and cobalt ions: theme and variations. BioMetals 18:399-405.


Eitinger, T. 2004. In vivo production of active nickel superoxide dismutase from Prochlorococcus marinus MIT9313 is dependent on its cognate peptidase. Journal of Bacteriology 186:7821-7825.
[J. Bacteriol.]


Hebbeln, P. and T. Eitinger. 2004. Heterologous production and characterization of bacterial nickel/cobalt permeases. FEMS Microbiology Letters 230:129-135.
[FEMS Microbiol. Lett.]


Schwartz, E., A. Henne, R. Cramm, T. Eitinger, B. Friedrich and G. Gottschalk. 2003. Complete nucleotide sequence of pHG1: A Ralstonia eutropha H16 megaplasmid encoding key enzymes of H2-based lithoautotrophy and anaerobiosis. Journal of Molecular Biology 332:369-383.


Degen, O. and T. Eitinger. 2002. Substrate specificity of nickel/cobalt permeases: Insights from mutants altered in transmembrane domains I and II. Journal of Bacteriology 184:3569-3577.
[J. Bacteriol.]


Eitinger, T. 2001. Microbial Nickel Transport. In Microbial Transport Systems (Winkelmann, G., Ed.), pp. 397-417, Wiley-VCH, Weinheim, Germany.


Eitinger, T. 2000. Mikrobielle Transporter für Ni2+-Ionen. BIOspektrum 6:456.


Eitinger, T., O. Degen, U. Böhnke and M. Müller. 2000. Nic1p, a relative of bacterial transition metal permeases in Schizosaccharomyces pombe, provides nickel ion for urease biosynthesis. Journal of Biological Chemistry 275:18029-18033.
[J. Biol. Chem.]


Eitinger, T. and M.-A. Mandrand-Berthelot. 2000. Nickel transport systems in microorganisms. Archives of Microbiology 173:1-9.


Degen, O., M. Kobayashi, S. Shimizu and T. Eitinger. 1999. Selective transport of divalent cations by transition metal permeases: The Alcaligenes eutrophus HoxN and the Rhodococcus rhodochrous NhlF. Archives of Microbiology 171:139-145.


Eitinger, T., L. Wolfram, J. Dernedde, I. Wolf, N. Patenge and B. Friedrich. 1997. Nickel metabolism in Alcaligenes eutrophus: Uptake by a Ni2+-specific permease and metal insertion into the hydrogenases. In Deutsche Forschungsgemeinschaft, Bioinorganic Chemistry, Transition Metals in Biology and their Coordination Chemistry. (Trautwein, A.X., Ed.),  pp. 37-50, Wiley-VCH , Weinheim.


Eitinger, T., L. Wolfram, O. Degen and C. Anthon. 1997. A Ni2+ binding motif is the basis of high affinity transport of the Alcaligenes eutrophus nickel permease. Journal of Biological Chemistry 272:17139-17144.
[J. Biol. Chem.]


Eitinger, T. and B. Friedrich. 1997. Microbial nickel transport and incorporation into hydrogenases. In Transition Metals in Microbial Metabolism. (Winkelmann, G. and Carrano, C.J., Eds.), pp. 235-256, Harwood Academic Publishers, Amsterdam, The Netherlands.


Eitinger, T. and B. Friedrich. 1997. Microbial nickel transport and incorporation into hydrogenases. In Transition Metals in Microbial Metabolism. (Winkelmann, G. and Carrano, C.J., Hrsg.). S. 235-256, Harwod Academic Publishers, Amsterdam.


Dernedde, J., T. Eitinger, N. Patenge and B. Friedrich. 1996. hyp gene products in Alcaligenes eutrophus are part of a hydrogenase maturation system. European Journal of Biochemistry 235:351-358.
[Eur. J. Biochem.]


Wolfram, L., B. Friedrich and T. Eitinger. 1995. The Alcaligenes eutrophus protein HoxN  mediates nickel transport in Escherichia coli. Journal of Bacteriology  177:1840-1843.
[J. Bacteriol.]


Friedrich, B., M. Bernhard, J. Dernedde, T. Eitinger, O. Lenz, C. Massanz and E. Schwartz. 1995. Hydrogen oxidation in Alcaligenes. In Microbial Growth on C1 Compounds. (Lidstrom, M.E. and Tabita, F.R., Eds.), pp. 110-117, Kluwer Academic Publishers, Dordrecht, Boston, London.


Eitinger, T. and B. Friedrich. 1994. A topological model for the high-affinity nickel transporter of Alcaligenes eutrophus. Molecular Microbiology 12:1025-1032.


Kuczius, T., T. Eitinger, R. d´Ari, H. Castorph and D. Kleiner. 1991. The gltF gene of Klebsiella pneumoniae: Cloning and initial characterization. Molecular and General Genetetics 229:479-482.


Wolfram, L., T. Eitinger and B. Friedrich. 1991. Construction and properties of a triprotein containing the high-affinity nickel transporter of Alcaligenes eutrophus. FEBS Letters 283:109-112.
[FEBS Lett.]


Eitinger, T. and B. Friedrich. 1991. Cloning, nucleotide sequence, and heterologous expression of a high-affinity nickel transport gene from Alcaligenes eutrophus. Journal of Biological Chemistry 266:3222-3227.
[J. Biol. Chem.]


Friedrich, B., C. Böcker, G. Eberz, T. Eitinger, K. Horstmann, C. Kortlüke, D. Römermann, E. Schwartz, A. Tran-Betcke, U. Warnecke and J. Warrelmann. 1990. Genes of hydrogen oxidation and denitrification form two clusters on megaplasmid pHG1 of Alcaligenes eutrophus. In: Pseudomonas: Biotransformation, Pathogenesis, and Evolving Biotechnology. (Silver, S. et al., Eds.), pp. 408-419, American Society for Microbiology, Washington D.C., U.S.A.


Eberz, G., T. Eitinger and B. Friedrich. 1989. Genetic determinants of a nickel-specific transport system are part of the plasmid-encoded hydrogenase gene cluster in Alcaligenes eutrophus. Journal of Bacteriology 171:1340-1345.
[J. Bacteriol.]