Scientific Program
Genome Editing with CRISPR
September 4 - 6, 2019
Humboldt-Universität zu Berlin
Annual conference of the German Genetics Society:
GENOME EDITING USING CRISPR
Program
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WEDNESDAY, September 4, 2019 |
12.00 – 14.00 Registration
14.00 Opening remarks: Ann Ehrenhofer-Murray
SESSION: “Class2” CRISPR-Cas systems
Chair: Ann Ehrenhofer-Murray
14.15 – 15.00 KEYNOTE LECTURE:
Emmanuelle Charpentier, MPI for Infection Biology, Berlin
t.b.a.
15.00 – 15.30 Virginijus Siksnys, Vilnius University, Institute of
Biotechnology Lithuania
Mining CRISPR-Cas systems: from Cas9s to auxiliary proteins
15.30 – 16.00 Dipali Sashital, Iowa State University, Ames, IA
Pervasive off-target and double-stranded DNA nicking by
CRISPR-Cas12a
16.00 - 16.30 Chase Beisel, Helmholtz Institute for RNA-based Infection
Research (HIRI), Würzburg
Characterization of Cas12a nucleases reveals diverse PAM
profiles between closely-related orthologs
Coffee break
SESSION: “Class 1” systems
Chair: Emmanuelle Charpentier
17.00 – 17.30 Peter Fineran, University of Otago, New Zealand
The regulation and activity of Class 1 CRISPR-Cas systems
17.30 – 18.00 Malcom White, St. Andrews University, UK
Ring War: virus:host conflict involving type III CRISPR
systems
18.00 – 18.30 John van der Oost, University Wageningen, NL
The Cascade complex - from biology to applications
18.30 – 19.00 Lennart Randau, Max-Planck-Institute for Terrestrial
Microbiology, Marburg
Structural and functional insights into Type IV
CRISPR-Cas systems
19.00 Welcome reception and Poster Session I
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THURSDAY, September 5, 2019 |
SESSION: Anti-CRISPR proteins
Chair: Malcolm White
9.00 – 9.30 Karen L. Maxwell, University of Toronto, Canada
The role of Anti CRISPR in the phage-host evolutionary
arms race
9.30 – 10.00 Joe Bondy-Denomy, UCSF
Evasion of CRISPR nucleases by jumbo bacteriophages
10.00 – 10.20 Dimitrios Laurin Wagner, Charité Universitätsmedizin Berlin
T cell immunity toward CRISPR-associated nucleases
Coffee break
SESSION:CRISPR-Cas technology and applications
Chair: Chase Beisel
10.45 – 11.15 Alekos Simoni, Imperial College London, UK
CRISPR-based population editing for vector control
11.15 – 11.45 Holger Puchta, Karlsruhe Institute of Technology,
Germany
CRISPR/Cas mediated genome engineering: a revolution for
plant biology and breeding
11.45 – 12.05 Cornelia Hampe, TaKaRa Bio Europe
A fast and reliable method for SNP screening in genome
editing experiments
12.05 – 12.25 Chunyu Liao, Helmholtz-Zentrum für RNA-basierte
Infektionsforschung, Würzburg
Modular one-pot assembly of CRISPR arrays enables
library generation and reveals factors influencing crRNA
biogenesis
Lunch break
13.00 – 13.30 Gesellschaft für Genetik Members Meeting
13.30 – 16.00 Speed talks and Poster Session II
SESSION: Adaptation
Chair: Lennart Randau
16.00 – 16.30 Francisco Mojica, University of Alicante, Spain
Determinants of CRISPR adaptation preferences, still
an open issue
16.30 – 17.00 Stan J. J. Brouns, TU Delft, NL
How microbes keep their CRISPR memories functional and
up to date
17.00 – 17.30 Anita Marchfelder, Universität Ulm, Germany
Self-targeting induced adaptation
17.30 – 17.50 Minja Velimirovic, Universite Laval/CHUL, Quebec
Increasing the genome-targeting scope of base editing using
Streptococcus thermophilus CRISPR1-Cas9 system
17.50 – 18.10 Daphne Collias, Helmholtz-Zentrum für RNA-basierte
Infektionsforschung (HIRI), Würzburg
A positive, growth-based PAM screen reveals non-canonical
motifs recognized by the S. pyogenes Cas9
18.10 – 18.30 Edda Schulz, Max Planck Institute for Molecular
Genetics, Berlin
A hierarchical CRISPR screening approach to identify genes
underlying sex differences in mouse embryonic stem cells
19.00 Conference Dinner:
HABEL am Reichstag, Luisenstraße 19, 10117 Berlin
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FRIDAY, September 6, 2019 |
SESSION: CRISPR-Cas functions beyond defense
Chair: Stan Brouns
9.00 – 9.30 Eugene V. Koonin, National Center for Biotechnology
Information, NIH, Bethesda, MD
Diversity, evolution, and exaptation of CRISPR-Cas systems
9.30 – 10.00 Cynthia Sharma, Universität Würzburg
Targeting of endogenous RNAs by the CRISPR-Cas9
nuclease in Campylobacter jejuni
10.00 – 10.20 Ed Bolt, University of Nottingham, UK
A new sgRNA– targeted DNA integration protein for genome
editing that short – circuits homology dependent DNA repair
Coffee break
SESSION: Prizes and Awards
Chair: Ann Ehrenhofer-Murray
10.45 – 11.45 MAX-DELBRÜCK-LECTURE:
Detlef Weigel, MPI für Entwicklungsbiologie, Tübingen
Epistasis, the spice of life: Lessons from the study of the
plant immune system
11.45 – 12.30 GATEFF Award for Excellent PhD Thesis
t.b.a.
CELEBRATION: Honorary Membership for Prof. Elisabeth Gateff
Lunch break
13.30 – 14.30 Poster Session III
SESSION: Ecology & Evolution
Chair: Peter Fineran
14.30 – 15.00 Uri Gophna, Tel Aviv University, Israel
CRISPR-Cas as a moderator of the flexible genome
15.00 – 15.30 Edze Westra, University of Exeter, UK
Mixed mode transmission of phages drives loss of Type
I CRISPR-Cas immune systems from bacteria
15.30 – 15.50 Israela Turgeman-Grott, Tel Aviv University
The host, the CRISPR and the integrated virus
15.50 – 16.10 Stanislav Indik, University of Veterinary Medicine
Vienna
A novel toolkit for the efficient delivery of Cas9/sgRNA
complexes to cells
16.15 Concluding remarks and departure
19.30 – 21.00 WISSENSCHAFT IM SAURIERSAAL
(MUSEUM FÜR NATURKUNDE, Invalidenstr. 43,
10117 Berlin):
„Genomeditierung - Wo sind die Grenzen?“
Public event with Detlef Weigel (MPI für Entwicklungsbiolgie,
Tübingen) and Sheree Domingo (artist)
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