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Humboldt-Universität zu Berlin - Molekulare Parasitologie

Publikationen

(1) Arroyo-Olarte RD, Burrowers JF, Kuchipudi A, Helms JB, Biswas A, Dunay IR, Lucius R, Gupta N (2015); Phosphatidylthreonine and lipid-mediated control parasite virulence. PLoS Biology, in press

 

(2) Blume M, Nitzsche R, Sternberg U, Gerlic M, Masters SL, Gupta N, McConville MJ (2015); A Toxoplasma gondii gluconeogenic enzyme contributes to robust central carbon metabolism and is essential for replication and virulence. Cell Host & Microbe, 18: 210-20

 

(3) Hartmann A, Hellmund M, Lucius R, Voelker DR, Gupta N (2014); Phosphatidylethanolamine synthesis in the parasite mitochondrion is required for efficient growth but dispensable for survival of Toxoplasma gondii. Journal of Biological Chemistry, 289: 6809-24

 

(4) Schmid M, Heitlinger E, Spork S, Mollenkopf HP, Lucius R, Gupta N (2014); Eimeria falciformis infection of the mouse caecum identifies opposing roles of IFNg-regulated host pathways for the parasite development. Mucosal Immunology, 7(4): 969-82

 

(5) Hartmann A, Arroyo-Olarte RD, Imkeller K, Hegemann P, Lucius R, Gupta N (2013); Optogenetic modulation of an adenylate cyclase in Toxoplasma gondii demonstrates a requirement of parasite cAMP for host-cell invasion and stage differentiation. Journal of Biological Chemistry, 288: 13705-17

 

(6) Qureshi B, Hoffmann N, Arroyo-Olarte RD, Nickl B, Höhne W, Jungblut P, Lucius R, Scheerer P, Gupta N (2013); Dynein Light Chain 8a of Toxoplasma gondii, a unique conoid-localized β-strand-swapped homodimer, is required for an efficient parasite growth FASEB J, 27: 1034-47

 

(7) Gupta N, Hartmann A, Lucius R, Voelker DR (2012) The obligate intracellular parasite Toxoplasma gondii secretes a soluble phosphatidylserine decarboxylase. Journal of Biological Chemistry, 287: 22938-47

 

(8) Schmid M, Lehmann MJ, Lucius R, Gupta N (2012) Apicomplexan parasite, Eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in the mouse. Journal of Biological Chemistry, 287: 20197-207

 

(9) Sampels V, Hartmann A, Dietrich I, Coppens I, Sheiner L, Striepen B, Herrmann A, Lucius R, Gupta N (2012) Conditional mutagenesis of a novel choline kinase demonstrates the plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii. Journal of Biological Chemistry, 287: 16289-99

 

(10) Blume M, Hliscs M, Contreras D, Sanchez M, Landfear S, Lucius R, Matuschewski K, Gupta N (2011) A constitutive pan-hexose permease in Plasmodium and models for high-throughput screening of anti-malarial sugar analogs. FASEB J, 25: 1218-29

 

(11) Shao D, Liu Y, Liu X, Zhu L, Cui Y, Cui A, Qiao A, Kong X, Liu Y, Chen Q, Gupta N, Fang F, Chang Y (2010) PGC-1b-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRa. Mitochondrion, 10: 516–27

 

(12) Zhu LL, Liu Y, Cui AF, Shao D, Liang JC, Liu XJ, Chen Y, Gupta N, Fang FD, Chang Y (2010) PGC-1a coactivates estrogen receptor a to induce the expression of glucokinase. American Journal of Physiology, 298: E1210–8

 

(13) Kong X, Fan H, Liu X, Wang R, Liang J, Gupta N, Chen Y, Fang F, Chang Y (2009) Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Molecular Pharmacology, 76: 854-60

 

(14) Blume M, Contreras DR, Landfear S, Fleige T, Soldati DF, Lucius R, Gupta N (2009) Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis. Proceedings of National Academy of Sciences USA, 106: 12998–3003

 

(15) Liu X, Feng Q, Chen Y, Zuo J, Gupta N, Chang Y, Fang F (2009) Proteomics-based identification of differentially-expressed proteins including galectin-1 in the blood plasma of type 2 diabetic patients. Journal of Proteome Research, 8: 1255-62

 

(16) Jiang ZB, Song HT, Gupta N, Ma LX, Wu ZB (2007) Cell surface display of functionally active lipases from Yarrowia lipolytica in Pichia pastoris. Protein Expression Purification, 56: 35-9

 

(17) Yang C, Yang Y, Gupta N, Liu X, He A, Liu L, Zuo J, Chang Y, Fang F (2007) Pentaspan membrane glycoprotein, prominin-1, is involved in glucose metabolism and cytoskeleton alteration. Biochemistry (M), 72: 854-62

 

(18) He A, Zhu L, Gupta N, Chang Y, Fang F (2007) Overexpression of miR-29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Molecular Endocrinology, 21: 2785-94

 

(19) Liu XJ, Yang C, Gupta N, Zuo J, Chang YS, Fang FD (2007) Protein kinase C-ζ regulation of GLUT4 translocation by actin remodeling in CHO cells. Journal of Molecular Medicine, 85: 851–61

 

(20) Gupta N, Zahn MM, Coppens I, Joiner KA, Voelker DR (2005) Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth. Journal of Biological Chemistry, 280: 16345–53

 

MANUSCRIPTS IN REVIEW

Nitzsche R, Zagoriy V, Lucius R, Gupta N; Metabolic cooperation of glucose and glutamine is essential for the lytic cycle of intracellular parasite T. gondii (under minor revision, JBC)