Selected Publications
BioMiner: Paving the Way for Personalized Medicine
Bauer C., Stec K., Glintschert A., Gruden K., Schichor C., Or-Guil M., Selbig J., Schuchhardt J., Cancer Inform, 14:55-63
A major hindrance in antibody affinity maturation investigation: we never succeeded in falsifying the hypothesis of single-step selection
Or-Guil, M. and Faro J., Front Immunol, May 26;5:237
Quantifying the Length and Variance of the Eukaryotic Cell Cycle Phases by a Stochastic Model and Dual Nucleoside Pulse Labelling
Weber, T. S., Jaehnert I., Schichor C, Or-Guil M., and Carneiro J., PLOS Comp Biol, 10(7):e1003616
How oligoclonal are germinal centers? A new method for estimating clonal diversity from immunohistological sections
Faro, J. and Or-Guil M., BMC Bioinformatics, 14 Suppl 6:S8
Immune System Modeling and Analysis
Mehr R., Davenport M., De Boer R. J., Molina-Paris C., Or-Guil M., Zarnitsyna V. (Eds.): Frontiers in Immunology, Frontiers Research Topic EBook, Frontiers Media SA
A minimal model of peptide binding predicts ensemble properties of serum antibodies.
Greiff V., Redestig H., Lück J., Bruni N., Valai A., Hartmann S., Rausch S., Schuchhardt J., Or-Guil M., BMC Genomics 2012, 13:79.
A "crossomics" study analysing variability of different components in peripheral blood of healthy caucasoid individuals.
Gruden K., Hren M., Herman A., Blejec A., Albrecht T., Selbig J., Bauer C., Schuchardt J., Or-Guil M., Zupančič K., Svajger U., Stabuc B., Ihan A., Kopitar A.N., Ravnikar M., Knežević M., Rožman P., Jeras M., PLoS One 2012; 7(1).
Is there a typical germinal center? A large-scale immunohistological study on the cellular composition of germinal centers during the hapten-carrier-driven primary immune response in mice.
Wittenbrink N., Klein A., Weiser A.A., Schuchhardt J., Or-Guil M., J. Immunol. 2011, 187(12), 6185-96.
GCImagePresenter: A Database on Histological Images of Murine Splenic Germinal Centers
Wittenbrink N., Or-Guil M.
Affinity maturation of B cells involves not only a few but a whole spectrum of relevant mutations.
Weiser A.A., Wittenbrink N., Zhang L., Schmelzer A.I., Valai A., Or-Guil M., Int. Immunol. 2011, 23(5), 345-56.
Broad volume distributions indicate nonsynchronized growth and suggest sudden collapses of germinal center B cell populations.
Wittenbrink N., Weber T.S., Klein A., Weiser A.A., Zuschratter W., Sibila M., Schuchhardt J., Or-Guil M., J. Immunol. 2010, 184(3), 1339-47.
Epitope mapping using randomly generated peptide libraries.
Bongartz J., Bruni N., Or-Guil M., Methods Mol. Biol. 2009, 524, 237-46.
Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation
M. Or-Guil, N. Wittenbrink, A. A. Weiser, J. Schuchhardt, Immunological Reviews 2007, 216, 130.
Affinity profiling using the peptide microarray technology: A case study
V. Tapia, J. Bongartz, M. Schutkowski, N. Bruni, A. Weiser, B. Ay, R. Volkmer, M. Or-Guil, Analytical Biochemistry 2007, 363, 108.
Defining reduced amino acid sets with a new substitution matrix based solely on binding affinities
A. A. Weiser, R. Volkmer, M. Or-Guil, Biomat 2006, 259-268.
A mathematical model of protein degradation by the proteasome.
F. Luciani, C. Kesmir, M. Mishto, M. Or-Guil, R. J. de Boer, Biophys. J. 2005, 88, 2422.
SPOT synthesis: reliability of array-based measurement of peptide binding affinity.
A. A. Weiser, M. Or-Guil, V. Tapia, A. Leichsenring, J. Schuchhardt, C. Frommel, R. Volkmer-Engert, Analytical Biochemistry 2005, 342, 300.
Recycling probability and dynamical properties of germinal center reactions.
M. Meyer-Hermann, A. Deutsch, M. Or-Guil, J Theor Biol 2001, 210, 265.
Dispersion gap and localized spiral waves in a model for intracellular Ca2+ dynamics.
M. Falcke, M. Or-Guil, M. Bar, Phys Rev Lett 2000, 84, 4753.