Humboldt-Universität zu Berlin - Molekulare Zellbiologie/ Molecular Cell Biology

ORCID: 0000-0001-8709-1942

https://orcid.org/0000-0001-8709-1942

MoDorado: Enhanced detection of tRNA modifications in nanopore sequencing by off-label use of modification callers. Franziskus N. M. Rübsam, Wang Liu-Wei, Yu Sun, Bhargesh Indravadan Patel, Wiep van der Toorn, Michael Piechotta, Christoph Dieterich, Max von Kleist, Ann E. Ehrenhofer-Murray, Nucleic Acids Res 2025, doi: https://doi.org/10.1101/2025.02.18.638820

The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine.

Burtnyak L, Yuan Y, Stojek E, Pan X, Gunaratne L, Silveira d'Almeida G, Fergus C, Martinelli M, J Reed C, Fernandez J, Patel BI, Marquez I, Ehrenhofer-Murray AE, Swairjo MA, Alfonzo JD, Green BD, Kelly VP, de Crécy-Lagard V. Proc Natl Acad Sci U S A. 2025 Jun 24;122(25):e2425364122. doi: 10.1073/pnas.2425364122. Epub 2025 Jun 17. PMID: 40526720

Queuine: A Bacterial Nucleobase Shaping Translation in Eukaryotes.

Ehrenhofer-Murray AE. J Mol Biol. 2025 Aug 15;437(16):168985. doi: 10.1016/j.jmb.2025.168985. Epub 2025 Feb 15.

A role for β-1,6- and β-1,3-glucans in kinetochore function in Saccharomyces cerevisiae.

Kshirsagar R, Munhoven A, Tran Nguyen TM, Ehrenhofer-Murray AE. Genetics. 2024 Feb 7;226(2):iyad195. doi: 10.1093/genetics/iyad195.

Detection of queuosine and queuosine precursors in tRNAs by direct RNA sequencing.

Sun Y, Piechotta M, Naarmann-de Vries I, Dieterich C, Ehrenhofer-Murray AE. Nucleic Acids Res. 2023 Nov 10;51(20):11197-11212. doi: 10.1093/nar/gkad826.

A dual-purpose polymerase engineered for direct sequencing of pseudouridine and queuosine.

Huber LB, Kaur N, Henkel M, Marchand V, Motorin Y, Ehrenhofer-Murray AE, Marx A. Nucleic Acids Res. 2023 May 8;51(8):3971-3987. doi: 10.1093/nar/gkad177.

Methylation of CENP-A/Cse4 on arginine 143 and lysine 131 regulates kinetochore stability in yeast.

Tran Nguyen TM, Munhoven A, Samel-Pommerencke A, Kshirsagar R, Cuomo A, Bonaldi T, Ehrenhofer-Murray AE. Genetics. 2023 Apr 6;223(4):iyad028. doi: 10.1093/genetics/iyad028.

Queuosine salvage in fission yeast by Qng1-mediated hydrolysis to queuine.

Patel BI, Heiss M, Samel-Pommerencke A, Carell T, Ehrenhofer-Murray AE. Biochem Biophys Res Commun. 2022 Oct 8;624:146-150. doi: 10.1016/j.bbrc.2022.07.104. Epub 2022 Jul 31.

The ATAD2/ANCCA homolog Yta7 cooperates with Scm3HJURP to deposit Cse4CENP-A at the centromere in yeast.

Shahnejat-Bushehri S, Ehrenhofer-Murray AE. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5386-5393. doi: 10.1073/pnas.1917814117. Epub 2020 Feb 20.

The kinetochore module Okp1CENP-Q/Ame1CENP-U is a reader for N-terminal modifications on the centromeric histone Cse4CENP-A.

Anedchenko EA, Samel-Pommerencke A, Tran Nguyen TM, Shahnejat-Bushehri S, Pöpsel J, Lauster D, Herrmann A, Rappsilber J, Cuomo A, Bonaldi T, Ehrenhofer-Murray AE. EMBO J. 2019 Jan 3;38(1):e98991. doi: 10.15252/embj.201898991. Epub 2018 Nov 2.

Queuosine-modified tRNAs confer nutritional control of protein translation.

Tuorto F, Legrand C, Cirzi C, Federico G, Liebers R, Müller M, Ehrenhofer-Murray AE, Dittmar G, Gröne HJ, Lyko F. EMBO J. 2018 Sep 14;37(18):e99777. doi: 10.15252/embj.201899777. Epub 2018 Aug 9.

Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation.

Samel A, Cuomo A, Bonaldi T, Ehrenhofer-Murray AE. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9029-34. doi: 10.1073/pnas.1120968109. Epub 2012 May 21.

Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.

Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE. Genes Dev. 2011 Sep 1;25(17):1835-46. doi: 10.1101/gad.17175111.