Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL (Ang. Int Ed Chem, April '23)
Berta Martins, María González-Viegas and Holger Dobbek together with colleagues from the group of Roderich Süssmuth (UniSysCat, TU Berlin, Germany) used X-ray crystallography and NMR together with other biochemical tools to underline the principles of domain organisation and substrate recruitmentof class IV and III lanthipeptide synthases.
Arnar Sigurdsson, Berta M. Martins, Simon A. Düttmann, Martin Jasyk, Benjamin Dimos-Röhl, Felix Schöpf, Manuel Gemander, Dr. Caroline H. Knittel, Dr. Romina Schnegotzki, Bianca Schmid, Simone Kosol, Lea Pommerening, María Gonzáles-Viegas, Maria Seidel, Manuela Hügelland, Silke Leimkühler, Holger Dobbek, Andi Mainz, Roderich D. Süssmuth (2023) Ang. Int Ed Chem, e202302490, DOI: 10.1002/anie.202302490