Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL (Angewandte Chemie, April 2023)
Berta Martins, María González-Viegas, and Holger Dobbek joined forces with colleagues from Roderich Süssmuth's group (UniSysCat, TU Berlin, Germany) to elucidate the principles of domain organisation and substrate recruitment of class IV and III lanthipeptide synthases. They used X-ray crystallography and NMR together with other biochemical tools.
Arnar Sigurdsson, Berta M. Martins, Simon A. Düttmann, Martin Jasyk, Benjamin Dimos-Röhl, Felix Schöpf, Manuel Gemander, Dr. Caroline H. Knittel, Dr. Romina Schnegotzki, Bianca Schmid, Simone Kosol, Lea Pommerening, María Gonzáles-Viegas, Maria Seidel, Manuela Hügelland, Silke Leimkühler, Holger Dobbek, Andi Mainz, Roderich D. Süssmuth (2023) Ang. Int Ed Chem, e202302490, DOI: 10.1002/anie.202302490