Publications
https://www.biologie.hu-berlin.de/en/groupsites/struktbio/publications
https://www.biologie.hu-berlin.de/@@site-logo/og_logo.png
Humboldt-Universität zu Berlin
|
Department of Biology
|
Structural Biology / Biochemistry
|
Publications
Publications
2022
|
Basak Yudhajeet, Jeoung Jae-Hun, Domnik Lilith, Ruickoldt Jakob, Dobbek Holger Substrate Activation at the Ni,Fe Cluster of CO Dehydrogenases: The Influence of the Protein Matrix ACS Catalysis. 12711-12719. 10.1021/acscatal.2c02922 |
|
Jeoung J.H., Nicklisch S., Dobbek H. Structural basis for coupled ATP-driven electron transfer in the double-cubane cluster protein Proceedings of the National Academy of Sciences of the United States of America. 31. 10.1073/pnas.2203576119 |
|
Lennartz F., Jeoung J.H., Ruenger S., Dobbek H., Weiss M.S. Determining the oxidation state of elements by X-ray crystallography Acta Crystallographica Section D: Structural Biology. 238-247. 10.1107/S2059798321013048 |
|
Jeoung J.H., Fesseler J., Domnik L., Klemke F., Sinnreich M., Teutloff C., Dobbek H. A Morphing [4Fe-3S-nO]-Cluster within a Carbon Monoxide Dehydrogenase Scaffold Angewandte Chemie - International Edition. 18. 10.1002/anie.202117000 |
|
Ruickoldt Jakob, Basak Yudhajeet, Domnik Lilith, Jeoung Jae-Hun, Dobbek Holger On the Kinetics of CO2 Reduction by Ni, Fe-CO Dehydrogenases ACS Catalysis. 13131-13142. 10.1021/acscatal.2c02221 |
|
Simon Philipp S., Makita Hiroki, Bogacz Isabel, Fuller Franklin, Bhowmick Asmit, Hussein Rana, Ibrahim Mohamed, Zhang Miao, Chatterjee Ruchira, Cheah Mun Hon, Chernev Petko, Doyle Margaret D., Brewster Aaron S., Alonso‐Mori Roberto, Sauter Nicholas K., Bergmann Uwe, Dobbek Holger, Zouni Athina, Messinger Johannes, Kern Jan, Yachandra Vittal K., Yano Junko Capturing the sequence of events during the water oxidation reaction in photosynthesis using XFELs FEBS Letters. 30-37. 10.1002/1873-3468.14527 |
2021
|
Neumann F., Dobbek H. ATP Binding and a Second Reduction Enables a Conformationally Gated Uphill Electron Transfer ACS Catalysis. 14. 8565-8575. 10.1021/acscatal.1c01038 |
|
Hussein R., Ibrahim M., Bhowmick A., Simon P.S., Chatterjee R., Lassalle L., Doyle M., Bogacz I., Kim I.S., Cheah M.H., Gul S., de Lichtenberg C., Chernev P., Pham C.C., Young I.D., Carbajo S., Fuller F.D., Alonso-Mori R., Batyuk A., Sutherlin K.D., Brewster A.S., Bolotovsky R., Mendez D., Holton J.M., Moriarty N.W., Adams P.D., Bergmann U., Sauter N.K., Dobbek H., Messinger J., Zouni A., Kern J., Yachandra V.K., Yano J. Structural dynamics in the water and proton channels of photosystem II during the S2 to S3 transition Nature Communications. 1. 10.1038/s41467-021-26781-z |
|
Jeoung J.H., Rünger S., Haumann M., Neumann B., Klemke F., Davis V., Fischer A., Dau H., Wollenberger U., Dobbek H. Bimetallic Mn, Fe, Co, and Ni Sites in a Four-Helix Bundle Protein: Metal Binding, Structure, and Peroxide Activation Inorganic Chemistry. 23. 17498-17508. 10.1021/acs.inorgchem.1c01919 |
|
Ibrahim M., Moriarty N.W., Kern J., Holton J.M., Brewster A.S., Bhowmick A., Bergmann U., Zouni A., Messinger J., Yachandra V.K., Yano J., Dobbek H., Sauter N.K., Adams P.D. Clear evidence of binding of Ox to the oxygen-evolving complex of photosystem II is best observed in the omit map Proceedings of the National Academy of Sciences of the United States of America. 24. 10.1073/pnas.2102342118 |
2020
|
Benvenuti M., Meneghello M., Guendon C., Jacq-Bailly A., Jeoung J.H., Dobbek H., Léger C., Fourmond V., Dementin S. The two CO-dehydrogenases of Thermococcus sp. AM4 Biochimica et Biophysica Acta - Bioenergetics. 7. 10.1016/j.bbabio.2020.148188 |
|
Ilina Y., Martins B.M., Jeoung J.H., Dobbek H. Nickel, Iron, Sulfur Sites Metal ions in life sciences. 10.1515/9783110589757-017 |
|
Gerland L., Friedrich D., Hopf L., Donovan E.J., Wallmann A., Erdmann N., Diehl A., Bommer M., Buzar K., Ibrahim M., Schmieder P., Dobbek H., Zouni A., Bondar A.N., Dau H., Oschkinat H. pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes ChemBioChem. 11. 1597-1604. 10.1002/cbic.201900739 |
|
Jeoung J.H., Martins B.M., Dobbek H. Double-Cubane [8Fe9S] Clusters: A Novel Nitrogenase-Related Cofactor in Biology ChemBioChem. 12. 1710-1716. 10.1002/cbic.202000016 |
|
Ibrahim M., Fransson T., Chatterjee R., Cheah M.H., Hussein R., Lassalle L., Sutherlin K.D., Young I.D., Fuller F.D., Gul S., Kim I.S., Simon P.S., de Lichtenberg C., Chernev P., Bogacz I., Pham C.C., Orville A.M., Saichek N., Northen T., Batyuk A., Carbajo S., Alonso-Mori R., Tono K., Owada S., Bhowmick A., Bolotovsky R., Mendez D., Moriarty N.W., Holton J.M., Dobbek H., Brewster A.S., Adams P.D., Sauter N.K., Bergmann U., Zouni A., Messinger J., Kern J., Yachandra V.K., Yano J. Untangling the sequence of events during the S2 → S3 transition in photosystem II and implications for the water oxidation mechanism Proceedings of the National Academy of Sciences of the United States of America. 23. 12624-12635. 10.1073/pnas.2000529117 |
2019
|
Baumann T, Hauf M, Schildhauer F, Eberl KB, Durkin PM, Deniz E, Lö}ffler JG, Acevedo-Rocha CG, Jaric J, Martins BM, Dobbek H, Bredenbeck J, Budisa N Site-Resolved Observation of Vibrational Energy Transfer Using a Genetically Encoded Ultrafast Heater Angew Chem Int Ed Engl. 9. 2899-2903. 10.1002/anie.201812995 |
|
Han R., Rempfer K., Zhang M., Dobbek H., Zouni A., Dau H., Luber S. Investigating the Structure and Dynamics of Apo-Photosystem II ChemCatChem. 16. 4072-4080. 10.1002/cctc.201900351 |
|
Kemmler L., Ibrahim M., Dobbek H., Zouni A., Bondar A.N. Dynamic water bridging and proton transfer at a surface carboxylate cluster of photosystem II Physical Chemistry Chemical Physics. 45. 25449-25466. 10.1039/c9cp03926k |
|
Jeoung JH, Martins BM, Dobbek H X-Ray Crystallography of Carbon Monoxide Dehydrogenases Methods Mol Biol. 167-178. 10.1007/978-1-4939-8864-8_11 |
|
Dobbek H. Structure and Mechanism of Ni- and Fe-containing Carbon Monoxide Dehydrogenases Oxygen Production and Reduction in Artificial and Natural Systems. 307-318. 10.1142/9789813276925_0015 |
|
Ilina Y., Lorent C., Katz S., Jeoung J.H., Shima S., Horch M., Zebger I., Dobbek H. X-ray Crystallography and Vibrational Spectroscopy Reveal the Key Determinants of Biocatalytic Dihydrogen Cycling by [NiFe] Hydrogenases Angewandte Chemie - International Edition. 51. 18710-18714. 10.1002/anie.201908258 |
2018
|
Jeoung J., Dobbek H. ATP-dependent substrate reduction at an [Fe8S9] double-cubane cluster Proceedings of the National Academy of Sciences of the United States of America. 12. 2994-2999. 10.1073/pnas.1720489115 |
|
Stehling O., Jeoung J.H., Freibert S.A., Paul V.D., Bänfer S., Niggemeyer B., Rösser R., Dobbek H., Lill R. Function and crystal structure of the dimeric P-loop ATPase CFD1 coordinating an exposed [4Fe-4S] cluster for transfer to apoproteins Proceedings of the National Academy of Sciences of the United States of America. 39. E9085-E9094. 10.1073/pnas.1807762115 |
|
Hussein R., Ibrahim M., Chatterjee R., Coates L., Müh F., Yachandra V.K., Yano J., Kern J., Dobbek H., Zouni A. Optimizing Crystal Size of Photosystem II by Macroseeding: Toward Neutron Protein Crystallography Crystal Growth and Design. 1. 85-94. 10.1021/acs.cgd.7b00878 |
|
Keller S., Kunze C., Bommer M., Paetz C., Menezes R., Svatoš A., Dobbek H., Schubert T. Selective utilization of benzimidazolylnorcobamides as cofactors by the tetrachloroethene reductive dehalogenase of Sulfurospirillum multivorans Journal of Bacteriology. 8. 10.1128/JB.00584-17 |
|
Sullivan B., Archibald R., Langan P.S., Dobbek H., Bommer M., McFeeters R.L., Coates L., Wang X., Gallmeier F., Carpenter J.M., Lynch V., Langan P. Improving the accuracy and resolution of neutron crystallographic data by three-dimensional profile fitting of Bragg peaks in reciprocal space Acta Crystallographica Section D: Structural Biology. 11. 1085-1095. 10.1107/S2059798318013347 |
|
Kern J., Chatterjee R., Young I.D., Fuller F.D., Lassalle L., Ibrahim M., Gul S., Fransson T., Brewster A.S., Alonso-Mori R., Hussein R., Zhang M., Douthit L., de Lichtenberg C., Cheah M.H., Shevela D., Wersig J., Seuffert I., Sokaras D., Pastor E., Weninger C., Kroll T., Sierra R.G., Aller P., Butryn A., Orville A.M., Liang M., Batyuk A., Koglin J.E., Carbajo S., Boutet S., Moriarty N.W., Holton J.M., Dobbek H., Adams P.D., Bergmann U., Sauter N.K., Zouni A., Messinger J., Yano J., Yachandra V.K. Structures of the intermediates of Kok’s photosynthetic water oxidation clock Nature. 7731. 421-425. 10.1038/s41586-018-0681-2 |
|
Wilk P., Uehlein M., Piwowarczyk R., Dobbek H., Mueller U., Weiss M. Structural basis for prolidase deficiency disease mechanisms FEBS Journal. 18. 3422-3441. 10.1111/febs.14620 |
2017
|
Dobbek H. Nitrogenase: A fuel-producing microbe Nature Chemical Biology. 2. 134-135. 10.1038/nchembio.2288 |
|
Homburg C., Bommer M., Wuttge S., Hobe C., Beck S., Dobbek H., Deutscher J., Licht A., Schneider E. Inducer exclusion in Firmicutes: insights into the regulation of a carbohydrate ATP binding cassette transporter from Lactobacillus casei BL23 by the signal transducing protein P-Ser46-HPr Molecular Microbiology. 1. 25-45. 10.1111/mmi.13680 |
|
Kielb P., Utesch T., Kozuch J., Jeoung J., Dobbek H., Mroginski M., Hildebrandt P., Weidinger I. Switchable Redox Chemistry of the Hexameric Tyrosine-Coordinated Heme Protein Journal of Physical Chemistry B. 16. 3955-3964 |
|
Wilk P., Uehlein M., Kalms J., Dobbek H., Mueller U., Weiss M. Substrate specificity and reaction mechanism of human prolidase FEBS Journal. 17. 2870-2885 |
|
Zhang M., Bommer M., Chatterjee R., Hussein R., Yano J., Dau H., Kern J., Dobbek H., Zouni A. Structural insights into the light-driven auto-assembly process of the wateroxidizing Mn4CaO5-cluster in photosystem II eLife |
|
Ciaccafava A., Tombolelli D., Domnik L., Jeoung J.H., Dobbek H., Mroginski M.A., Zebger I., Hildebrandt P. Carbon Monoxide Dehydrogenase Reduces Cyanate to Cyanide Angewandte Chemie - International Edition. 26. 7398-7401. 10.1002/anie.201703225 |
|
Kunze C., Bommer M., Hagen W., Uksa M., Dobbek H., Schubert T., Diekert G. Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer Nature Communications. 10.1038/ncomms15858 |
|
Domnik L., Merrouch M., Goetzl S., Jeoung J.H., Léger C., Dementin S., Fourmond V., Dobbek H. CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2 Angewandte Chemie - International Edition. 48. 15466-15469. 10.1002/anie.201709261 |
|
Werther T., Wahlefeld S., Salewski J., Kuhlmann U., Zebger I., Hildebrandt P., Dobbek H. Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase Nature Communications |
|
Hauf M, Richter F, Schneider T, Faidt T, Martins BM, Baumann T, Durkin P, Dobbek H, Jacobs K, Moeglich A, Budisa N Photoactivatable Mussel-Based Underwater Adhesive Proteins by an Expanded Genetic Code ChemBioChem. 1-6. 10.1002/cbic.201700327 |
|
Goetzl S., Teutloff C., Werther T., Hennig S., Jeoung J., Bittl R., Dobbek H. Protein Dynamics in the Reductive Activation of a B12-Containing Enzyme Biochemistry. 41. 5496-5502 |
|
Bommer M., Coates L., Dau H., Zouni A., Dobbek H. Protein crystallization and initial neutron diffraction studies of the photosystem II subunit PsbO Acta Crystallographica Section:F Structural Biology Communications. 9. 525-531 |
|
Dobbek H. Playing marble run to make methane Science. 6352. 642-643. 10.1126/science.aao2439 |
|
Schrapers P., Ilina J., Gregg C.M., Mebs S., Jeoung J.H., Dau H., Dobbek H., Haumann M. Ligand binding at the A-cluster in full-length or truncated acetyl-CoA synthase studied by X-ray absorption spectroscopy PLoS ONE. 2. 10.1371/journal.pone.0171039 |
2016
|
Jeoung J., Nianios D., Fetzner S., Dobbek H. Quercetin 2,4-Dioxygenase Activates Dioxygen in a Side-On O2-Ni Complex Angewandte Chemie - International Edition. 10. 3281-3284 |
|
Gregg C.M., Goetzl S., Jeoung J.H., Dobbek H. AcsF catalyzes the ATP-dependent insertion of Nickel into the Ni, Ni-[4Fe4S] cluster of Acetyl-CoA synthase Journal of Biological Chemistry. 35. 18129-18138 |
|
Schrapers P., Mebs S., Goetzl S., Hennig S., Dau H., Dobbek H., Haumann M. Axial ligation and redox changes at the cobalt ion in cobalamin bound to Corrinoid Iron-Sulfur Protein (CoFeSP) or in solution characterized by XAS and DFT PLoS ONE. 7 |
|
Bommer M., Bondar A., Zouni A., Dobbek H., Dau H. Crystallographic and Computational Analysis of the Barrel Part of the PsbO Protein of Photosystem II: Carboxylate-Water Clusters as Putative Proton Transfer Relays and Structural Switches Biochemistry. 33. 4626-4635 |
|
Dobbek H., Leys D. Insights into reductive dehalogenase function obtained from crystal structures Organohalide-Respiring Bacteria. 485-495 |
|
Peng L., Yarman A., Jetzschmann K., Jeoung J., Schad D., Dobbek H., Wollenberger U., Scheller F. Molecularly imprinted electropolymer for a hexameric heme protein with direct electron transfer and peroxide electrocatalysis Sensors (Switzerland). 3 |
|
Schäfer C., Bommer M., Hennig S., Jeoung J., Dobbek H., Lenz O. Structure of an Actinobacterial-Type [NiFe]-Hydrogenase Reveals Insight into O2-Tolerant H2 Oxidation Structure. 2. 285-292 |
|
Young I.D., Ibrahim M., Chatterjee R., Gul S., Fuller F.D., Koroidov S., Brewster A.S., Tran R., Alonso-Mori R., Kroll T., Michels-Clark T., Laksmono H., Sierra R.G., Stan C.A., Hussein R., Zhang M., Douthit L., Kubin M., De Lichtenberg C., Vo Pham L., Nilsson H., Cheah M.H., Shevela D., Saracini C., Bean M.A., Seuffert I., Sokaras D., Weng T.C., Pastor E., Weninger C., Fransson T., Lassalle L., Bräuer P., Aller P., Docker P.T., Andi B., Orville A.M., Glownia J.M., Nelson S., Sikorski M., Zhu D., Hunter M.S., Lane T.J., Aquila A., Koglin J.E., Robinson J., Liang M., Boutet S., Lyubimov A.Y., Uervirojnangkoorn M., Moriarty N.W., Liebschner D., Afonine P.V., Waterman D.G., Evans G., Wernet P., Dobbek H., Weis W.I., Brunger A.T., Zwart P.H., Adams P.D., Zouni A., Messinger J., Bergmann U., Sauter N.K., Kern J., Yachandra V.K., Yano J. Structure of photosystem II and substrate binding at room temperature Nature. 7633. 453-457 |
|
Schrapers P., Mebs S., Ilina Y., Warner D., Wörmann C., Schuth N., Kositzki R., Dau H., Limberg C., Dobbek H., Haumann M. The binuclear nickel center in the A-cluster of acetyl-CoA synthase (ACS) and two biomimetic dinickel complexes studied by X-ray absorption and emission spectroscopy Journal of Physics: Conference Series |
|
Ciaccafava A., Tombolelli D., Domnik L., Fesseler J., Jeoung J., Dobbek H., Mroginski M., Zebger I., Hildebrandt P. When the inhibitor tells more than the substrate: The cyanide-bound state of a carbon monoxide dehydrogenase Chemical Science. 5. 3162-3171 |
2015
|
Merrouch M., Hadj-Saïd J., Domnik L., Dobbek H., Léger C., Dementin S., Fourmond V. O2 Inhibition of Ni-Containing CO Dehydrogenase Is Partly Reversible Chemistry - A European Journal. 52. 18934-18938 |
|
Fesseler J., Jeoung J., Dobbek H. How the [NiFe4S4] Cluster of CO Dehydrogenase Activates CO2 and NCO- Angewandte Chemie - International Edition. 29. 8560-8564 |
|
Tanne J., Jeoung J.H., Peng L., Yarman A., Dietzel B., Schulz B., Schad D., Dobbek H., Wollenberger U., Bier F.F., Scheller F.W. Direct Electron Transfer and Bioelectrocatalysis by a Hexameric, Heme Protein at Nanostructured Electrodes Electroanalysis. 10. 2262-2267 |
|
Peng L., Utesch T., Yarman A., Jeoung J., Steinborn S., Dobbek H., Mroginski M., Tanne J., Wollenberger U., Scheller F. Surface-tuned electron transfer and electrocatalysis of hexameric tyrosine-coordinated heme protein Chemistry - A European Journal. 20. 7596-7602 |
2014
|
Jeoung J.H., Fesseler J., Goetzl S., Dobbek H. Carbon monoxide. Toxic gas and fuel for anaerobes and aerobes: Carbon monoxide dehydrogenases Metal Ions in Life Sciences. 37-69 |
|
Bommer M., Kunze C., Fesseler J., Schubert T., Diekert G., Dobbek H. Structural basis for organohalide respiration Science. 6208. 455-458 |
|
Hellmich J., Bommer M., Burkhardt A., Ibrahim M., Kern J., Meents A., Müh F., Dobbek H., Zouni A. Native-like Photosystem II Superstructure at 2.44 Å Resolution through Detergent Extraction from the Protein Crystal Structure. 11. 1607-1615 |
|
Jeoung J., Goetzl S., Hennig S., Fesseler J., Wörmann C., Dendra J., Dobbek H. The extended reductive acetyl-CoA pathway:ATpases in metal cluster maturation and reductive activation Biological Chemistry. 5. 545-558 |
|
Hennig S., Goetzl S., Jeoung J., Bommer M., Lendzian F., Hildebrandt P., Dobbek H. ATP-induced electron transfer by redox-selective partner recognition Nature Communications |
2013
|
Nehrkorn J, Martins BM, Holldack K, Stoll S, Dobbek H, Bittl R, Schnegg A Zero-field splittings in metHb and metMb with aquo and fluoro ligands: a FD-FT THz-EPR study Mol Phys. 2696-2707. doi:10.1080/00268976.2013.809806 |
|
Jeoung J., Bommer M., Lin T., Dobbek H. Visualizing the substrate-, superoxo-, alkylperoxo-, and product-bound states at the nonheme Fe(II) site of homogentisate dioxygenase Proceedings of the National Academy of Sciences of the United States of America. 31. 12625-12630 |
|
Appel A., Bercaw J., Bocarsly A., Dobbek H., Dubois D., Dupuis M., Ferry J., Fujita E., Hille R., Kenis P., Kerfeld C., Morris R., Peden C., Portis A., Ragsdale S., Rauchfuss T., Reek J., Seefeldt L., Thauer R., Waldrop G. Frontiers, opportunities, and challenges in biochemical and chemical catalysis of CO2 fixation Chemical Reviews. 8. 6621-6658 |
2012
|
Knauer S.H., Hartl-Spiegelhauer O., Schwarzinger S., Hänzelmann P., Dobbek H. The Fe(II)/ α -ketoglutarate-dependent taurine dioxygenases from Pseudomonas putida and Escherichia coli are tetramers FEBS Journal. 5. 816-831 |
|
Jeoung J., Dobbek H. n-Butyl isocyanide oxidation at the [NiFe 4S 4OH x] cluster of CO dehydrogenase Journal of Biological Inorganic Chemistry. 2. 167-173 |
|
Wuttge S., Bommer M., Jäger F., Martins B., Jacob S., Licht A., Scheffel F., Dobbek H., Schneider E. Determinants of substrate specificity and biochemical properties of the sn-glycerol-3-phosphate ATP binding cassette transporter (UgpB-AEC2) of Escherichia coli Molecular Microbiology. 4. 908-920 |
|
Knauer S., Buckel W., Dobbek H. On the ATP-dependent activation of the radical enzyme (R)-2- hydroxyisocaproyl-CoA dehydratase Biochemistry. 33. 6609-6622 |
|
Hennig S., Jeoung J., Goetzl S., Dobbek H. Redox-dependent complex formation by an ATP-dependent activator of the corrinoid/iron-sulfur protein Proceedings of the National Academy of Sciences of the United States of America. 14. 5235-5240 |
|
Meister W., Hennig S., Jeoung J., Lendzian F., Dobbek H., Hildebrandt P. Complex formation with the activator RACo affects the corrinoid structure of CoFeSP Biochemistry. 36. 7040-7042 |
|
Jakob R., Geitner A., Weininger U., Balbach J., Dobbek H., Schmid F. Structural and energetic basis of infection by the filamentous bacteriophage IKe Molecular Microbiology. 6. 1124-1138 |
|
Buckel W, Zhang J, Friedrich P, Parthasarathy A, Li H, Djurdjevic I, Dobbek H, Martins BM Enzyme catalyzed radical dehydrations of hydroxy acids Biochim Biophys Acta. 1278-1290 |
|
Lin T.Y., Werther T., Jeoung J.H., Dobbek H. Suppression of electron transfer to dioxygen by charge transfer and electron transfer complexes in the FAD-dependent reductase componentof toluene dioxygenase Journal of Biological Chemistry. 45. 38338-38346 |
2011
|
Knauer S., Buckel W., Dobbek H. Structural basis for reductive radical formation and electron recycling in (R)-2-hydroxyisocaproyl-CoA dehydratase Journal of the American Chemical Society. 12. 4342-4347 |
|
Dobbek H. Structural aspects of mononuclear Mo/W-enzymes Coordination Chemistry Reviews. 1104-1116 |
|
Goetzl S., Jeoung J.H., Hennig S.E., Dobbek H. Structural basis for electron and methyl-group transfer in a methyltransferase system operating in the reductive acetyl-CoA pathway Journal of Molecular Biology. 1. 96-109 |
|
Lorenz S.H., Jakob R.P., Weininger U., Balbach J., Dobbek H., Schmid F.X. The filamentous phages fd and IF1 use different mechanisms to infect escherichia coli Journal of Molecular Biology. 4. 989-1003 |
2010
|
Jeoung J.H., Giese T., Grünwald M., Dobbek H. Crystal structure of the ATP-dependent maturation factor of Ni,Fe-containing carbon monoxide dehydrogenases Journal of Molecular Biology. 4. 1165-1179 |
|
Spiegelhauer O., Werther T., Mende S., Knauer S.H., Dobbek H. Determinants of Substrate Binding and Protonation in the Flavoenzyme Xenobiotic Reductase A Journal of Molecular Biology. 2. 286-298 |
|
Jakob R.P., Zierer B.K., Weininger U., Hofmann S.D., Lorenz S.H., Balbach J., Dobbek H., Schmid F.X. Elimination of a Cis-proline-containing loop and turn optimization stabilizes a protein and accelerates its folding Journal of Molecular Biology. 2. 331-346 |
|
Spiegelhauer O., Mende S., Dickert F., Knauer S.H., Ullmann G.M., Dobbek H. Cysteine as a modulator residue in the active site of xenobiotic reductase A: A structural, thermodynamic and kinetic study Journal of Molecular Biology. 1. 66-82 |
2009
|
Jeoung J.H., Giese T., Grünwald M., Dobbek H. CooC1 from Carboxydothermus hydrogenoformans is a nickel-binding ATPase Biochemistry. 48. 11505-11513 |
|
Jeoung J., Dobbek H. Structural basis of cyanide inhibition of Ni, Fe-containing carbon monoxide dehydrogenase Journal of the American Chemical Society. 29. 9922-9923 |
|
Wagener N., Pierik A., Ibdah A., Hille R., Dobbek H. The Mo-Se active site of nicotinate dehydrogenase Proceedings of the National Academy of Sciences of the United States of America. 27. 11055-11060 |
|
Spiegelhauer O., Dickert F., Mende S., Niks D., Hille R., Ullmann M., Dobbek H. Kinetic characterization of xenobiotic reductase A from Pseudomonas putida 86 Biochemistry. 48. 11412-11420 |
2008
|
Kather I., Jakob R.P., Dobbek H., Schmid F.X. Increased Folding Stability of TEM-1 β-Lactamase by In Vitro Selection Journal of Molecular Biology. 1. 238-251 |
|
Kather I., Jakob R., Dobbek H., Schmid F.X. Changing the Determinants of Protein Stability from Covalent to Non-Covalent Interactions by In Vitro Evolution: A Structural and Energetic Analysis Journal of Molecular Biology. 4. 1040-1054 |
|
Dobbek H. How biological Fe-S centers activate CO2 Wie Biologische Fe-S-Zentren CO2 Aktivieren Nachrichten aus der Chemie. 734-737 |
2007
|
Jeoung J.H., Dobbek H. Carbon dioxide activation at the Ni,Fe-cluster of anaerobic carbon monoxide dehydrogenase Science. 5855. 1461-1464 |
|
Jeoung J, Pippig DA, Martins BM, Wagener N, Dobbek H HTHP: a novel class of hexameric, tyrosine-coordinated heme proteins Journal of Molecular Biology. 4. 1122{--}1131 |
|
Zoldák G., Redecke L., Svergun D.I., Konarev P.V., Voertler C.S., Dobbek H., Sedlák E., Sprinzl M. Release factors 2 from Escherichia coli and Thermus thermophilus: Structural, spectroscopic and microcalorimetric studies Nucleic Acids Research. 4. 1343-1353 |
|
Einsle O., Andrade S., Dobbek H., Meyer J., Rees D. Assignment of individual metal redox states in a metalloprotein by crystallographic refinement at multiple X-ray wavelengths Journal of the American Chemical Society. 8. 2210-2211 |
2006
|
Griese J.J., P. Jakob R., Schwarzinger S., Dobbek H. Xenobiotic Reductase A in the Degradation of Quinoline by Pseudomonas putida 86: Physiological Function, Structure and Mechanism of 8-Hydroxycoumarin Reduction Journal of Molecular Biology. 1. 140-152 |
|
Svetlitchnaia T., Svetlitchnyi V., Meyer O., Dobbek H. Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis Proceedings of the National Academy of Sciences of the United States of America. 39. 14331-14336 |
2005
|
Resch M., Dobbek H., Meyer O. Structural and functional reconstruction in situ of the [CuSMoO 2] active site of carbon monoxide dehydrogenase from the carbon monoxide oxidizing eubacterium Oligotropha carboxidovorans Journal of Biological Inorganic Chemistry. 5. 518-528 |
|
Martins B., Svetlitchnaia T., Dobbek H. 2-Oxoquinoline 8-monooxygenase oxygenase component: Active site modulation by Rieske-[2Fe-2S] center oxidation/reduction Structure. 5. 817-824 |
2004
|
Martins B., Dobbek H., Çinkaya I., Buckel W., Messerschmidt A. Crystal structure of 4-hydroxybutyryl-CoA dehydratase: Radical catalysis involving a [4Fe-4S] cluster and flavin Proceedings of the National Academy of Sciences of the United States of America. 44. 15645-15649 |
|
Bonin I, Martins BM, Puranov V, Fetzner S, Huber R, Dobbek H Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase Structure. 8. 1425{--}1435 |
|
Dobbek H., Svetlitchnyi V., Liss J., Meyer O. Carbon Monoxide Induced Decomposition of the Active Site [Ni-4Fe-5S] Cluster of CO Dehydrogenase Journal of the American Chemical Society. 17. 5382-5387 |
|
Svetlitchnyi V., Dobbek H., Meyer-Klaucke W., Meins T., Thiele B., Römer P., Huber R., Meyer O. A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans Proceedings of the National Academy of Sciences of the United States of America. 2. 446-451 |
2002
|
Dobbek H., Huber R. The molybdenum and tungsten cofactors: A crystallographic view Metals Ions in Biological System: Molybdenum and Tungsten: Their Roles in Biological Processes. 227-263 |
|
Dobbek H., Gremer L., Kiefersauer R., Huber R., Meyer O. Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-Å resolution Proceedings of the National Academy of Sciences of the United States of America. 25. 15971-15976 |
2001
|
Dobbek H., Svetlitchnyi V., Gremer L., Huber R., Meyer O. Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster Science. 5533. 1281-1285 |
2000
|
Hänzelmann P., Dobbek H., Gremer L., Huber R., Meyer O. The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase Journal of Molecular Biology. 5. 1221-1235 |
|
Gremer L., Kellner S., Dobbek H., Huber R., Meyer O. Binding of flavin adenine dinucleotide to molybdenum-containing carbon monoxide dehydrogenase from Oligotropha carboxidovorans. Structural and functional analysis of a carbon monoxide dehydrogenase species in which the native flavoprotein has been replaced by its recombinant counterpart produced in Escherichia coli Journal of Biological Chemistry. 3. 1864-1872 |
|
Meyer O., Gremer L., Ferner R., Ferner M., Dobbek H., Gnida M., Meyer-Klaucke W., Huber R. The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase Biological Chemistry. 865-876 |
|
Kiefersauer R., Than M.E., Dobbek H., Gremer L., Melero M., Strobl S., Dias J.M., Soulimane T., Huber R. A novel free-mounting system for protein crystals: Transformation and improvement of diffraction power by accurately controlled humidity changes Journal of Applied Crystallography. 5. 1223-1230 |
1999
|
Dobbek H., Gremer L., Meyer O., Huber R. Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine Proceedings of the National Academy of Sciences of the United States of America. 16. 8884-8889 |
1997
|
Knäblein J., Dobbek H., Ehlert S., Schneider F. Isolation, Cloning, Sequence Analysis and X-Ray Structure of Dimethyl Sulfoxide/Trimethylamine N-Oxide Reductase from Rhodobactercapsulatus Biological Chemistry. 293-302 |
|
Knäblein J., Dobbek H., Schneider F. Organization of the DMSO Respiratory Operon of Rhodobactercapsulatus and Its Consequences for Homologous Expression of DMSOR/TMAOR Biological Chemistry. 303-308 |