Humboldt-Universität zu Berlin - Structural Biology / Biochemistry



Basak Yudhajeet, Jeoung Jae-Hun, Domnik Lilith, Ruickoldt Jakob, Dobbek Holger
Substrate Activation at the Ni,Fe Cluster of CO Dehydrogenases: The Influence of the Protein Matrix
ACS Catalysis. 12711-12719. 10.1021/acscatal.2c02922
Jeoung J.H., Nicklisch S., Dobbek H.
Structural basis for coupled ATP-driven electron transfer in the double-cubane cluster protein
Proceedings of the National Academy of Sciences of the United States of America. 31. 10.1073/pnas.2203576119
Lennartz F., Jeoung J.H., Ruenger S., Dobbek H., Weiss M.S.
Determining the oxidation state of elements by X-ray crystallography
Acta Crystallographica Section D: Structural Biology. 238-247. 10.1107/S2059798321013048
Jeoung J.H., Fesseler J., Domnik L., Klemke F., Sinnreich M., Teutloff C., Dobbek H.
A Morphing [4Fe-3S-nO]-Cluster within a Carbon Monoxide Dehydrogenase Scaffold
Angewandte Chemie - International Edition. 18. 10.1002/anie.202117000
Ruickoldt Jakob, Basak Yudhajeet, Domnik Lilith, Jeoung Jae-Hun, Dobbek Holger
On the Kinetics of CO2 Reduction by Ni, Fe-CO Dehydrogenases
ACS Catalysis. 13131-13142. 10.1021/acscatal.2c02221
Simon Philipp S., Makita Hiroki, Bogacz Isabel, Fuller Franklin, Bhowmick Asmit, Hussein Rana, Ibrahim Mohamed, Zhang Miao, Chatterjee Ruchira, Cheah Mun Hon, Chernev Petko, Doyle Margaret D., Brewster Aaron S., Alonso‐Mori Roberto, Sauter Nicholas K., Bergmann Uwe, Dobbek Holger, Zouni Athina, Messinger Johannes, Kern Jan, Yachandra Vittal K., Yano Junko
Capturing the sequence of events during the water oxidation reaction in photosynthesis using

FEBS Letters. 30-37. 10.1002/1873-3468.14527


Neumann F., Dobbek H.
ATP Binding and a Second Reduction Enables a Conformationally Gated Uphill Electron Transfer
ACS Catalysis. 14. 8565-8575. 10.1021/acscatal.1c01038
Hussein R., Ibrahim M., Bhowmick A., Simon P.S., Chatterjee R., Lassalle L., Doyle M., Bogacz I., Kim I.S., Cheah M.H., Gul S., de Lichtenberg C., Chernev P., Pham C.C., Young I.D., Carbajo S., Fuller F.D., Alonso-Mori R., Batyuk A., Sutherlin K.D., Brewster A.S., Bolotovsky R., Mendez D., Holton J.M., Moriarty N.W., Adams P.D., Bergmann U., Sauter N.K., Dobbek H., Messinger J., Zouni A., Kern J., Yachandra V.K., Yano J.
Structural dynamics in the water and proton channels of photosystem II during the S2 to S3 transition
Nature Communications. 1. 10.1038/s41467-021-26781-z
Jeoung J.H., Rünger S., Haumann M., Neumann B., Klemke F., Davis V., Fischer A., Dau H., Wollenberger U., Dobbek H.
Bimetallic Mn, Fe, Co, and Ni Sites in a Four-Helix Bundle Protein: Metal Binding, Structure, and Peroxide Activation
Inorganic Chemistry. 23. 17498-17508. 10.1021/acs.inorgchem.1c01919
Ibrahim M., Moriarty N.W., Kern J., Holton J.M., Brewster A.S., Bhowmick A., Bergmann U., Zouni A., Messinger J., Yachandra V.K., Yano J., Dobbek H., Sauter N.K., Adams P.D.
Clear evidence of binding of Ox to the oxygen-evolving complex of photosystem II is best observed in the omit map
Proceedings of the National Academy of Sciences of the United States of America. 24. 10.1073/pnas.2102342118


Benvenuti M., Meneghello M., Guendon C., Jacq-Bailly A., Jeoung J.H., Dobbek H., Léger C., Fourmond V., Dementin S.
The two CO-dehydrogenases of Thermococcus sp. AM4
Biochimica et Biophysica Acta - Bioenergetics. 7. 10.1016/j.bbabio.2020.148188
Ilina Y., Martins B.M., Jeoung J.H., Dobbek H.
Nickel, Iron, Sulfur Sites
Metal ions in life sciences. 10.1515/9783110589757-017
Gerland L., Friedrich D., Hopf L., Donovan E.J., Wallmann A., Erdmann N., Diehl A., Bommer M., Buzar K., Ibrahim M., Schmieder P., Dobbek H., Zouni A., Bondar A.N., Dau H., Oschkinat H.
pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes
ChemBioChem. 11. 1597-1604. 10.1002/cbic.201900739
Jeoung J.H., Martins B.M., Dobbek H.
Double-Cubane [8Fe9S] Clusters: A Novel Nitrogenase-Related Cofactor in Biology
ChemBioChem. 12. 1710-1716. 10.1002/cbic.202000016
Ibrahim M., Fransson T., Chatterjee R., Cheah M.H., Hussein R., Lassalle L., Sutherlin K.D., Young I.D., Fuller F.D., Gul S., Kim I.S., Simon P.S., de Lichtenberg C., Chernev P., Bogacz I., Pham C.C., Orville A.M., Saichek N., Northen T., Batyuk A., Carbajo S., Alonso-Mori R., Tono K., Owada S., Bhowmick A., Bolotovsky R., Mendez D., Moriarty N.W., Holton J.M., Dobbek H., Brewster A.S., Adams P.D., Sauter N.K., Bergmann U., Zouni A., Messinger J., Kern J., Yachandra V.K., Yano J.
Untangling the sequence of events during the S2 → S3 transition in photosystem II and implications for the water oxidation mechanism
Proceedings of the National Academy of Sciences of the United States of America. 23. 12624-12635. 10.1073/pnas.2000529117


Baumann T, Hauf M, Schildhauer F, Eberl KB, Durkin PM, Deniz E, Lö}ffler JG, Acevedo-Rocha CG, Jaric J, Martins BM, Dobbek H, Bredenbeck J, Budisa N
Site-Resolved Observation of Vibrational Energy Transfer Using a Genetically Encoded Ultrafast Heater
Angew Chem Int Ed Engl. 9. 2899-2903. 10.1002/anie.201812995
Han R., Rempfer K., Zhang M., Dobbek H., Zouni A., Dau H., Luber S.
Investigating the Structure and Dynamics of Apo-Photosystem II
ChemCatChem. 16. 4072-4080. 10.1002/cctc.201900351
Kemmler L., Ibrahim M., Dobbek H., Zouni A., Bondar A.N.
Dynamic water bridging and proton transfer at a surface carboxylate cluster of photosystem II
Physical Chemistry Chemical Physics. 45. 25449-25466. 10.1039/c9cp03926k
Jeoung JH, Martins BM, Dobbek H
X-Ray Crystallography of Carbon Monoxide Dehydrogenases
Methods Mol Biol. 167-178. 10.1007/978-1-4939-8864-8_11
Dobbek H.
Structure and Mechanism of Ni- and Fe-containing Carbon Monoxide Dehydrogenases
Oxygen Production and Reduction in Artificial and Natural Systems. 307-318. 10.1142/9789813276925_0015
Ilina Y., Lorent C., Katz S., Jeoung J.H., Shima S., Horch M., Zebger I., Dobbek H.
X-ray Crystallography and Vibrational Spectroscopy Reveal the Key Determinants of Biocatalytic Dihydrogen Cycling by [NiFe] Hydrogenases
Angewandte Chemie - International Edition. 51. 18710-18714. 10.1002/anie.201908258


Jeoung J., Dobbek H.
ATP-dependent substrate reduction at an [Fe8S9] double-cubane cluster
Proceedings of the National Academy of Sciences of the United States of America. 12. 2994-2999. 10.1073/pnas.1720489115
Stehling O., Jeoung J.H., Freibert S.A., Paul V.D., Bänfer S., Niggemeyer B., Rösser R., Dobbek H., Lill R.
Function and crystal structure of the dimeric P-loop ATPase CFD1 coordinating an exposed [4Fe-4S] cluster for transfer to apoproteins
Proceedings of the National Academy of Sciences of the United States of America. 39. E9085-E9094. 10.1073/pnas.1807762115
Hussein R., Ibrahim M., Chatterjee R., Coates L., Müh F., Yachandra V.K., Yano J., Kern J., Dobbek H., Zouni A.
Optimizing Crystal Size of Photosystem II by Macroseeding: Toward Neutron Protein Crystallography
Crystal Growth and Design. 1. 85-94. 10.1021/acs.cgd.7b00878
Keller S., Kunze C., Bommer M., Paetz C., Menezes R., Svatoš A., Dobbek H., Schubert T.
Selective utilization of benzimidazolylnorcobamides as cofactors by the tetrachloroethene reductive dehalogenase of Sulfurospirillum multivorans
Journal of Bacteriology. 8. 10.1128/JB.00584-17
Sullivan B., Archibald R., Langan P.S., Dobbek H., Bommer M., McFeeters R.L., Coates L., Wang X., Gallmeier F., Carpenter J.M., Lynch V., Langan P.
Improving the accuracy and resolution of neutron crystallographic data by three-dimensional profile fitting of Bragg peaks in reciprocal space
Acta Crystallographica Section D: Structural Biology. 11. 1085-1095. 10.1107/S2059798318013347
Kern J., Chatterjee R., Young I.D., Fuller F.D., Lassalle L., Ibrahim M., Gul S., Fransson T., Brewster A.S., Alonso-Mori R., Hussein R., Zhang M., Douthit L., de Lichtenberg C., Cheah M.H., Shevela D., Wersig J., Seuffert I., Sokaras D., Pastor E., Weninger C., Kroll T., Sierra R.G., Aller P., Butryn A., Orville A.M., Liang M., Batyuk A., Koglin J.E., Carbajo S., Boutet S., Moriarty N.W., Holton J.M., Dobbek H., Adams P.D., Bergmann U., Sauter N.K., Zouni A., Messinger J., Yano J., Yachandra V.K.
Structures of the intermediates of Kok’s photosynthetic water oxidation clock
Nature. 7731. 421-425. 10.1038/s41586-018-0681-2
Wilk P., Uehlein M., Piwowarczyk R., Dobbek H., Mueller U., Weiss M.
Structural basis for prolidase deficiency disease mechanisms
FEBS Journal. 18. 3422-3441. 10.1111/febs.14620


Dobbek H.
Nitrogenase: A fuel-producing microbe
Nature Chemical Biology. 2. 134-135. 10.1038/nchembio.2288
Homburg C., Bommer M., Wuttge S., Hobe C., Beck S., Dobbek H., Deutscher J., Licht A., Schneider E.
Inducer exclusion in Firmicutes: insights into the regulation of a carbohydrate ATP binding cassette transporter from Lactobacillus casei BL23 by the signal transducing protein P-Ser46-HPr
Molecular Microbiology. 1. 25-45. 10.1111/mmi.13680
Kielb P., Utesch T., Kozuch J., Jeoung J., Dobbek H., Mroginski M., Hildebrandt P., Weidinger I.
Switchable Redox Chemistry of the Hexameric Tyrosine-Coordinated Heme Protein
Journal of Physical Chemistry B. 16. 3955-3964
Wilk P., Uehlein M., Kalms J., Dobbek H., Mueller U., Weiss M.
Substrate specificity and reaction mechanism of human prolidase
FEBS Journal. 17. 2870-2885
Zhang M., Bommer M., Chatterjee R., Hussein R., Yano J., Dau H., Kern J., Dobbek H., Zouni A.
Structural insights into the light-driven auto-assembly process of the wateroxidizing Mn4CaO5-cluster in photosystem II
Ciaccafava A., Tombolelli D., Domnik L., Jeoung J.H., Dobbek H., Mroginski M.A., Zebger I., Hildebrandt P.
Carbon Monoxide Dehydrogenase Reduces Cyanate to Cyanide
Angewandte Chemie - International Edition. 26. 7398-7401. 10.1002/anie.201703225
Kunze C., Bommer M., Hagen W., Uksa M., Dobbek H., Schubert T., Diekert G.
Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer
Nature Communications. 10.1038/ncomms15858
Domnik L., Merrouch M., Goetzl S., Jeoung J.H., Léger C., Dementin S., Fourmond V., Dobbek H.
CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2
Angewandte Chemie - International Edition. 48. 15466-15469. 10.1002/anie.201709261
Werther T., Wahlefeld S., Salewski J., Kuhlmann U., Zebger I., Hildebrandt P., Dobbek H.
Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase
Nature Communications
Hauf M, Richter F, Schneider T, Faidt T, Martins BM, Baumann T, Durkin P, Dobbek H, Jacobs K, Moeglich A, Budisa N
Photoactivatable Mussel-Based Underwater Adhesive Proteins by an Expanded Genetic Code
ChemBioChem. 1-6. 10.1002/cbic.201700327
Goetzl S., Teutloff C., Werther T., Hennig S., Jeoung J., Bittl R., Dobbek H.
Protein Dynamics in the Reductive Activation of a B12-Containing Enzyme
Biochemistry. 41. 5496-5502
Bommer M., Coates L., Dau H., Zouni A., Dobbek H.
Protein crystallization and initial neutron diffraction studies of the photosystem II subunit PsbO
Acta Crystallographica Section:F Structural Biology Communications. 9. 525-531
Dobbek H.
Playing marble run to make methane
Science. 6352. 642-643. 10.1126/science.aao2439
Schrapers P., Ilina J., Gregg C.M., Mebs S., Jeoung J.H., Dau H., Dobbek H., Haumann M.
Ligand binding at the A-cluster in full-length or truncated acetyl-CoA synthase studied by X-ray absorption spectroscopy
PLoS ONE. 2. 10.1371/journal.pone.0171039


Jeoung J., Nianios D., Fetzner S., Dobbek H.
Quercetin 2,4-Dioxygenase Activates Dioxygen in a Side-On O2-Ni Complex
Angewandte Chemie - International Edition. 10. 3281-3284
Gregg C.M., Goetzl S., Jeoung J.H., Dobbek H.
AcsF catalyzes the ATP-dependent insertion of Nickel into the Ni, Ni-[4Fe4S] cluster of Acetyl-CoA synthase
Journal of Biological Chemistry. 35. 18129-18138
Schrapers P., Mebs S., Goetzl S., Hennig S., Dau H., Dobbek H., Haumann M.
Axial ligation and redox changes at the cobalt ion in cobalamin bound to Corrinoid Iron-Sulfur Protein (CoFeSP) or in solution characterized by XAS and DFT
Bommer M., Bondar A., Zouni A., Dobbek H., Dau H.
Crystallographic and Computational Analysis of the Barrel Part of the PsbO Protein of Photosystem II: Carboxylate-Water Clusters as Putative Proton Transfer Relays and Structural Switches
Biochemistry. 33. 4626-4635
Dobbek H., Leys D.
Insights into reductive dehalogenase function obtained from crystal structures
Organohalide-Respiring Bacteria. 485-495
Peng L., Yarman A., Jetzschmann K., Jeoung J., Schad D., Dobbek H., Wollenberger U., Scheller F.
Molecularly imprinted electropolymer for a hexameric heme protein with direct electron transfer and peroxide electrocatalysis
Sensors (Switzerland). 3
Schäfer C., Bommer M., Hennig S., Jeoung J., Dobbek H., Lenz O.
Structure of an Actinobacterial-Type [NiFe]-Hydrogenase Reveals Insight into O2-Tolerant H2 Oxidation
Structure. 2. 285-292
Young I.D., Ibrahim M., Chatterjee R., Gul S., Fuller F.D., Koroidov S., Brewster A.S., Tran R., Alonso-Mori R., Kroll T., Michels-Clark T., Laksmono H., Sierra R.G., Stan C.A., Hussein R., Zhang M., Douthit L., Kubin M., De Lichtenberg C., Vo Pham L., Nilsson H., Cheah M.H., Shevela D., Saracini C., Bean M.A., Seuffert I., Sokaras D., Weng T.C., Pastor E., Weninger C., Fransson T., Lassalle L., Bräuer P., Aller P., Docker P.T., Andi B., Orville A.M., Glownia J.M., Nelson S., Sikorski M., Zhu D., Hunter M.S., Lane T.J., Aquila A., Koglin J.E., Robinson J., Liang M., Boutet S., Lyubimov A.Y., Uervirojnangkoorn M., Moriarty N.W., Liebschner D., Afonine P.V., Waterman D.G., Evans G., Wernet P., Dobbek H., Weis W.I., Brunger A.T., Zwart P.H., Adams P.D., Zouni A., Messinger J., Bergmann U., Sauter N.K., Kern J., Yachandra V.K., Yano J.
Structure of photosystem II and substrate binding at room temperature
Nature. 7633. 453-457
Schrapers P., Mebs S., Ilina Y., Warner D., Wörmann C., Schuth N., Kositzki R., Dau H., Limberg C., Dobbek H., Haumann M.
The binuclear nickel center in the A-cluster of acetyl-CoA synthase (ACS) and two biomimetic dinickel complexes studied by X-ray absorption and emission spectroscopy
Journal of Physics: Conference Series
Ciaccafava A., Tombolelli D., Domnik L., Fesseler J., Jeoung J., Dobbek H., Mroginski M., Zebger I., Hildebrandt P.
When the inhibitor tells more than the substrate: The cyanide-bound state of a carbon monoxide dehydrogenase
Chemical Science. 5. 3162-3171


Merrouch M., Hadj-Saïd J., Domnik L., Dobbek H., Léger C., Dementin S., Fourmond V.
O2 Inhibition of Ni-Containing CO Dehydrogenase Is Partly Reversible
Chemistry - A European Journal. 52. 18934-18938
Fesseler J., Jeoung J., Dobbek H.
How the [NiFe4S4] Cluster of CO Dehydrogenase Activates CO2 and NCO-
Angewandte Chemie - International Edition. 29. 8560-8564
Tanne J., Jeoung J.H., Peng L., Yarman A., Dietzel B., Schulz B., Schad D., Dobbek H., Wollenberger U., Bier F.F., Scheller F.W.
Direct Electron Transfer and Bioelectrocatalysis by a Hexameric, Heme Protein at Nanostructured Electrodes
Electroanalysis. 10. 2262-2267
Peng L., Utesch T., Yarman A., Jeoung J., Steinborn S., Dobbek H., Mroginski M., Tanne J., Wollenberger U., Scheller F.
Surface-tuned electron transfer and electrocatalysis of hexameric tyrosine-coordinated heme protein
Chemistry - A European Journal. 20. 7596-7602


Jeoung J.H., Fesseler J., Goetzl S., Dobbek H.
Carbon monoxide. Toxic gas and fuel for anaerobes and aerobes: Carbon monoxide dehydrogenases
Metal Ions in Life Sciences. 37-69
Bommer M., Kunze C., Fesseler J., Schubert T., Diekert G., Dobbek H.
Structural basis for organohalide respiration
Science. 6208. 455-458
Hellmich J., Bommer M., Burkhardt A., Ibrahim M., Kern J., Meents A., Müh F., Dobbek H., Zouni A.
Native-like Photosystem II Superstructure at 2.44 Å Resolution through Detergent Extraction from the Protein Crystal
Structure. 11. 1607-1615
Jeoung J., Goetzl S., Hennig S., Fesseler J., Wörmann C., Dendra J., Dobbek H.
The extended reductive acetyl-CoA pathway:ATpases in metal cluster maturation and reductive activation
Biological Chemistry. 5. 545-558
Hennig S., Goetzl S., Jeoung J., Bommer M., Lendzian F., Hildebrandt P., Dobbek H.
ATP-induced electron transfer by redox-selective partner recognition
Nature Communications


Nehrkorn J, Martins BM, Holldack K, Stoll S, Dobbek H, Bittl R, Schnegg A
Zero-field splittings in metHb and metMb with aquo and fluoro ligands: a FD-FT THz-EPR study
Mol Phys. 2696-2707. doi:10.1080/00268976.2013.809806
Jeoung J., Bommer M., Lin T., Dobbek H.
Visualizing the substrate-, superoxo-, alkylperoxo-, and product-bound states at the nonheme Fe(II) site of homogentisate dioxygenase
Proceedings of the National Academy of Sciences of the United States of America. 31. 12625-12630
Appel A., Bercaw J., Bocarsly A., Dobbek H., Dubois D., Dupuis M., Ferry J., Fujita E., Hille R., Kenis P., Kerfeld C., Morris R., Peden C., Portis A., Ragsdale S., Rauchfuss T., Reek J., Seefeldt L., Thauer R., Waldrop G.
Frontiers, opportunities, and challenges in biochemical and chemical catalysis of CO2 fixation
Chemical Reviews. 8. 6621-6658


Knauer S.H., Hartl-Spiegelhauer O., Schwarzinger S., Hänzelmann P., Dobbek H.
The Fe(II)/ α -ketoglutarate-dependent taurine dioxygenases from Pseudomonas putida and Escherichia coli are tetramers
FEBS Journal. 5. 816-831
Jeoung J., Dobbek H.
n-Butyl isocyanide oxidation at the [NiFe 4S 4OH x] cluster of CO dehydrogenase
Journal of Biological Inorganic Chemistry. 2. 167-173
Wuttge S., Bommer M., Jäger F., Martins B., Jacob S., Licht A., Scheffel F., Dobbek H., Schneider E.
Determinants of substrate specificity and biochemical properties of the sn-glycerol-3-phosphate ATP binding cassette transporter (UgpB-AEC2) of Escherichia coli
Molecular Microbiology. 4. 908-920
Knauer S., Buckel W., Dobbek H.
On the ATP-dependent activation of the radical enzyme (R)-2- hydroxyisocaproyl-CoA dehydratase
Biochemistry. 33. 6609-6622
Hennig S., Jeoung J., Goetzl S., Dobbek H.
Redox-dependent complex formation by an ATP-dependent activator of the corrinoid/iron-sulfur protein
Proceedings of the National Academy of Sciences of the United States of America. 14. 5235-5240
Meister W., Hennig S., Jeoung J., Lendzian F., Dobbek H., Hildebrandt P.
Complex formation with the activator RACo affects the corrinoid structure of CoFeSP
Biochemistry. 36. 7040-7042
Jakob R., Geitner A., Weininger U., Balbach J., Dobbek H., Schmid F.
Structural and energetic basis of infection by the filamentous bacteriophage IKe
Molecular Microbiology. 6. 1124-1138
Buckel W, Zhang J, Friedrich P, Parthasarathy A, Li H, Djurdjevic I, Dobbek H, Martins BM
Enzyme catalyzed radical dehydrations of hydroxy acids
Biochim Biophys Acta. 1278-1290
Lin T.Y., Werther T., Jeoung J.H., Dobbek H.
Suppression of electron transfer to dioxygen by charge transfer and electron transfer complexes in the FAD-dependent reductase componentof toluene dioxygenase
Journal of Biological Chemistry. 45. 38338-38346


Knauer S., Buckel W., Dobbek H.
Structural basis for reductive radical formation and electron recycling in (R)-2-hydroxyisocaproyl-CoA dehydratase
Journal of the American Chemical Society. 12. 4342-4347
Dobbek H.
Structural aspects of mononuclear Mo/W-enzymes
Coordination Chemistry Reviews. 1104-1116
Goetzl S., Jeoung J.H., Hennig S.E., Dobbek H.
Structural basis for electron and methyl-group transfer in a methyltransferase system operating in the reductive acetyl-CoA pathway
Journal of Molecular Biology. 1. 96-109
Lorenz S.H., Jakob R.P., Weininger U., Balbach J., Dobbek H., Schmid F.X.
The filamentous phages fd and IF1 use different mechanisms to infect escherichia coli
Journal of Molecular Biology. 4. 989-1003


Jeoung J.H., Giese T., Grünwald M., Dobbek H.
Crystal structure of the ATP-dependent maturation factor of Ni,Fe-containing carbon monoxide dehydrogenases
Journal of Molecular Biology. 4. 1165-1179
Spiegelhauer O., Werther T., Mende S., Knauer S.H., Dobbek H.
Determinants of Substrate Binding and Protonation in the Flavoenzyme Xenobiotic Reductase A
Journal of Molecular Biology. 2. 286-298
Jakob R.P., Zierer B.K., Weininger U., Hofmann S.D., Lorenz S.H., Balbach J., Dobbek H., Schmid F.X.
Elimination of a Cis-proline-containing loop and turn optimization stabilizes a protein and accelerates its folding
Journal of Molecular Biology. 2. 331-346
Spiegelhauer O., Mende S., Dickert F., Knauer S.H., Ullmann G.M., Dobbek H.
Cysteine as a modulator residue in the active site of xenobiotic reductase A: A structural, thermodynamic and kinetic study
Journal of Molecular Biology. 1. 66-82


Jeoung J.H., Giese T., Grünwald M., Dobbek H.
CooC1 from Carboxydothermus hydrogenoformans is a nickel-binding ATPase
Biochemistry. 48. 11505-11513
Jeoung J., Dobbek H.
Structural basis of cyanide inhibition of Ni, Fe-containing carbon monoxide dehydrogenase
Journal of the American Chemical Society. 29. 9922-9923
Wagener N., Pierik A., Ibdah A., Hille R., Dobbek H.
The Mo-Se active site of nicotinate dehydrogenase
Proceedings of the National Academy of Sciences of the United States of America. 27. 11055-11060
Spiegelhauer O., Dickert F., Mende S., Niks D., Hille R., Ullmann M., Dobbek H.
Kinetic characterization of xenobiotic reductase A from Pseudomonas putida 86
Biochemistry. 48. 11412-11420


Kather I., Jakob R.P., Dobbek H., Schmid F.X.
Increased Folding Stability of TEM-1 β-Lactamase by In Vitro Selection
Journal of Molecular Biology. 1. 238-251
Kather I., Jakob R., Dobbek H., Schmid F.X.
Changing the Determinants of Protein Stability from Covalent to Non-Covalent Interactions by In Vitro Evolution: A Structural and Energetic Analysis
Journal of Molecular Biology. 4. 1040-1054
Dobbek H.
How biological Fe-S centers activate CO2 Wie Biologische Fe-S-Zentren CO2 Aktivieren
Nachrichten aus der Chemie. 734-737


Jeoung J.H., Dobbek H.
Carbon dioxide activation at the Ni,Fe-cluster of anaerobic carbon monoxide dehydrogenase
Science. 5855. 1461-1464
Jeoung J, Pippig DA, Martins BM, Wagener N, Dobbek H
HTHP: a novel class of hexameric, tyrosine-coordinated heme proteins
Journal of Molecular Biology. 4. 1122{--}1131
Zoldák G., Redecke L., Svergun D.I., Konarev P.V., Voertler C.S., Dobbek H., Sedlák E., Sprinzl M.
Release factors 2 from Escherichia coli and Thermus thermophilus: Structural, spectroscopic and microcalorimetric studies
Nucleic Acids Research. 4. 1343-1353
Einsle O., Andrade S., Dobbek H., Meyer J., Rees D.
Assignment of individual metal redox states in a metalloprotein by crystallographic refinement at multiple X-ray wavelengths
Journal of the American Chemical Society. 8. 2210-2211


Griese J.J., P. Jakob R., Schwarzinger S., Dobbek H.
Xenobiotic Reductase A in the Degradation of Quinoline by Pseudomonas putida 86: Physiological Function, Structure and Mechanism of 8-Hydroxycoumarin Reduction
Journal of Molecular Biology. 1. 140-152
Svetlitchnaia T., Svetlitchnyi V., Meyer O., Dobbek H.
Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis
Proceedings of the National Academy of Sciences of the United States of America. 39. 14331-14336


Resch M., Dobbek H., Meyer O.
Structural and functional reconstruction in situ of the [CuSMoO 2] active site of carbon monoxide dehydrogenase from the carbon monoxide oxidizing eubacterium Oligotropha carboxidovorans
Journal of Biological Inorganic Chemistry. 5. 518-528
Martins B., Svetlitchnaia T., Dobbek H.
2-Oxoquinoline 8-monooxygenase oxygenase component: Active site modulation by Rieske-[2Fe-2S] center oxidation/reduction
Structure. 5. 817-824


Martins B., Dobbek H., Çinkaya I., Buckel W., Messerschmidt A.
Crystal structure of 4-hydroxybutyryl-CoA dehydratase: Radical catalysis involving a [4Fe-4S] cluster and flavin
Proceedings of the National Academy of Sciences of the United States of America. 44. 15645-15649
Bonin I, Martins BM, Puranov V, Fetzner S, Huber R, Dobbek H
Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase
Structure. 8. 1425{--}1435
Dobbek H., Svetlitchnyi V., Liss J., Meyer O.
Carbon Monoxide Induced Decomposition of the Active Site [Ni-4Fe-5S] Cluster of CO Dehydrogenase
Journal of the American Chemical Society. 17. 5382-5387
Svetlitchnyi V., Dobbek H., Meyer-Klaucke W., Meins T., Thiele B., Römer P., Huber R., Meyer O.
A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans
Proceedings of the National Academy of Sciences of the United States of America. 2. 446-451


Dobbek H., Huber R.
The molybdenum and tungsten cofactors: A crystallographic view
Metals Ions in Biological System: Molybdenum and Tungsten: Their Roles in Biological Processes. 227-263
Dobbek H., Gremer L., Kiefersauer R., Huber R., Meyer O.
Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-Å resolution
Proceedings of the National Academy of Sciences of the United States of America. 25. 15971-15976


Dobbek H., Svetlitchnyi V., Gremer L., Huber R., Meyer O.
Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster
Science. 5533. 1281-1285


Hänzelmann P., Dobbek H., Gremer L., Huber R., Meyer O.
The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase
Journal of Molecular Biology. 5. 1221-1235
Gremer L., Kellner S., Dobbek H., Huber R., Meyer O.
Binding of flavin adenine dinucleotide to molybdenum-containing carbon monoxide dehydrogenase from Oligotropha carboxidovorans. Structural and functional analysis of a carbon monoxide dehydrogenase species in which the native flavoprotein has been replaced by its recombinant counterpart produced in Escherichia coli
Journal of Biological Chemistry. 3. 1864-1872
Meyer O., Gremer L., Ferner R., Ferner M., Dobbek H., Gnida M., Meyer-Klaucke W., Huber R.
The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase
Biological Chemistry. 865-876
Kiefersauer R., Than M.E., Dobbek H., Gremer L., Melero M., Strobl S., Dias J.M., Soulimane T., Huber R.
A novel free-mounting system for protein crystals: Transformation and improvement of diffraction power by accurately controlled humidity changes
Journal of Applied Crystallography. 5. 1223-1230


Dobbek H., Gremer L., Meyer O., Huber R.
Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine
Proceedings of the National Academy of Sciences of the United States of America. 16. 8884-8889


Knäblein J., Dobbek H., Ehlert S., Schneider F.
Isolation, Cloning, Sequence Analysis and X-Ray Structure of Dimethyl Sulfoxide/Trimethylamine N-Oxide Reductase from Rhodobactercapsulatus
Biological Chemistry. 293-302
Knäblein J., Dobbek H., Schneider F.
Organization of the DMSO Respiratory Operon of Rhodobactercapsulatus and Its Consequences for Homologous Expression of DMSOR/TMAOR
Biological Chemistry. 303-308