Humboldt-Universität zu Berlin - Structural Biology / Biochemistry

Publications

2022

Lennartz F., Jeoung J.H., Ruenger S., Dobbek H., Weiss M.S.
Determining the oxidation state of elements by X-ray crystallography
Acta Crystallographica Section D: Structural Biology. 238-247. 10.1107/S2059798321013048
Jeoung J.H., Nicklisch S., Dobbek H.
Structural basis for coupled ATP-driven electron transfer in the double-cubane cluster protein
Proceedings of the National Academy of Sciences of the United States of America. 31. 10.1073/pnas.2203576119
Jeoung J.H., Fesseler J., Domnik L., Klemke F., Sinnreich M., Teutloff C., Dobbek H.
A Morphing [4Fe-3S-nO]-Cluster within a Carbon Monoxide Dehydrogenase Scaffold
Angewandte Chemie - International Edition. 18. 10.1002/anie.202117000

2021

Ibrahim M., Moriarty N.W., Kern J., Holton J.M., Brewster A.S., Bhowmick A., Bergmann U., Zouni A., Messinger J., Yachandra V.K., Yano J., Dobbek H., Sauter N.K., Adams P.D.
Clear evidence of binding of Ox to the oxygen-evolving complex of photosystem II is best observed in the omit map
Proceedings of the National Academy of Sciences of the United States of America. 24. 10.1073/pnas.2102342118
Hussein R., Ibrahim M., Bhowmick A., Simon P.S., Chatterjee R., Lassalle L., Doyle M., Bogacz I., Kim I.S., Cheah M.H., Gul S., de Lichtenberg C., Chernev P., Pham C.C., Young I.D., Carbajo S., Fuller F.D., Alonso-Mori R., Batyuk A., Sutherlin K.D., Brewster A.S., Bolotovsky R., Mendez D., Holton J.M., Moriarty N.W., Adams P.D., Bergmann U., Sauter N.K., Dobbek H., Messinger J., Zouni A., Kern J., Yachandra V.K., Yano J.
Structural dynamics in the water and proton channels of photosystem II during the S2 to S3 transition
Nature Communications. 1. 10.1038/s41467-021-26781-z
Neumann F., Dobbek H.
ATP Binding and a Second Reduction Enables a Conformationally Gated Uphill Electron Transfer
ACS Catalysis. 14. 8565-8575. 10.1021/acscatal.1c01038
Jeoung J.H., Rünger S., Haumann M., Neumann B., Klemke F., Davis V., Fischer A., Dau H., Wollenberger U., Dobbek H.
Bimetallic Mn, Fe, Co, and Ni Sites in a Four-Helix Bundle Protein: Metal Binding, Structure, and Peroxide Activation
Inorganic Chemistry. 23. 17498-17508. 10.1021/acs.inorgchem.1c01919

2020

Jeoung J.H., Martins B.M., Dobbek H.
Double-Cubane [8Fe9S] Clusters: A Novel Nitrogenase-Related Cofactor in Biology
ChemBioChem. 12. 1710-1716. 10.1002/cbic.202000016
Ilina Y., Martins B.M., Jeoung J.H., Dobbek H.
Nickel, Iron, Sulfur Sites
Metal ions in life sciences. 10.1515/9783110589757-017
Gerland L., Friedrich D., Hopf L., Donovan E.J., Wallmann A., Erdmann N., Diehl A., Bommer M., Buzar K., Ibrahim M., Schmieder P., Dobbek H., Zouni A., Bondar A.N., Dau H., Oschkinat H.
pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes
ChemBioChem. 11. 1597-1604. 10.1002/cbic.201900739
Benvenuti M., Meneghello M., Guendon C., Jacq-Bailly A., Jeoung J.H., Dobbek H., Léger C., Fourmond V., Dementin S.
The two CO-dehydrogenases of Thermococcus sp. AM4
Biochimica et Biophysica Acta - Bioenergetics. 7. 10.1016/j.bbabio.2020.148188
Ibrahim M., Fransson T., Chatterjee R., Cheah M.H., Hussein R., Lassalle L., Sutherlin K.D., Young I.D., Fuller F.D., Gul S., Kim I.S., Simon P.S., de Lichtenberg C., Chernev P., Bogacz I., Pham C.C., Orville A.M., Saichek N., Northen T., Batyuk A., Carbajo S., Alonso-Mori R., Tono K., Owada S., Bhowmick A., Bolotovsky R., Mendez D., Moriarty N.W., Holton J.M., Dobbek H., Brewster A.S., Adams P.D., Sauter N.K., Bergmann U., Zouni A., Messinger J., Kern J., Yachandra V.K., Yano J.
Untangling the sequence of events during the S2 → S3 transition in photosystem II and implications for the water oxidation mechanism
Proceedings of the National Academy of Sciences of the United States of America. 23. 12624-12635. 10.1073/pnas.2000529117

2019

Baumann T, Hauf M, Schildhauer F, Eberl KB, Durkin PM, Deniz E, Lö}ffler JG, Acevedo-Rocha CG, Jaric J, Martins BM, Dobbek H, Bredenbeck J, Budisa N
Site-Resolved Observation of Vibrational Energy Transfer Using a Genetically Encoded Ultrafast Heater
Angew Chem Int Ed Engl. 9. 2899-2903. 10.1002/anie.201812995
Dobbek H.
Structure and Mechanism of Ni- and Fe-containing Carbon Monoxide Dehydrogenases
Oxygen Production and Reduction in Artificial and Natural Systems. 307-318. 10.1142/9789813276925_0015
Ilina Y., Lorent C., Katz S., Jeoung J.H., Shima S., Horch M., Zebger I., Dobbek H.
X-ray Crystallography and Vibrational Spectroscopy Reveal the Key Determinants of Biocatalytic Dihydrogen Cycling by [NiFe] Hydrogenases
Angewandte Chemie - International Edition. 51. 18710-18714. 10.1002/anie.201908258
Kemmler L., Ibrahim M., Dobbek H., Zouni A., Bondar A.N.
Dynamic water bridging and proton transfer at a surface carboxylate cluster of photosystem II
Physical Chemistry Chemical Physics. 45. 25449-25466. 10.1039/c9cp03926k
Han R., Rempfer K., Zhang M., Dobbek H., Zouni A., Dau H., Luber S.
Investigating the Structure and Dynamics of Apo-Photosystem II
ChemCatChem. 16. 4072-4080. 10.1002/cctc.201900351
Jeoung JH, Martins BM, Dobbek H
X-Ray Crystallography of Carbon Monoxide Dehydrogenases
Methods Mol Biol. 167-178. 10.1007/978-1-4939-8864-8_11

2018

Hussein R., Ibrahim M., Chatterjee R., Coates L., Müh F., Yachandra V.K., Yano J., Kern J., Dobbek H., Zouni A.
Optimizing Crystal Size of Photosystem II by Macroseeding: Toward Neutron Protein Crystallography
Crystal Growth and Design. 1. 85-94. 10.1021/acs.cgd.7b00878
Stehling O., Jeoung J.H., Freibert S.A., Paul V.D., Bänfer S., Niggemeyer B., Rösser R., Dobbek H., Lill R.
Function and crystal structure of the dimeric P-loop ATPase CFD1 coordinating an exposed [4Fe-4S] cluster for transfer to apoproteins
Proceedings of the National Academy of Sciences of the United States of America. 39. E9085-E9094. 10.1073/pnas.1807762115
Kern J., Chatterjee R., Young I.D., Fuller F.D., Lassalle L., Ibrahim M., Gul S., Fransson T., Brewster A.S., Alonso-Mori R., Hussein R., Zhang M., Douthit L., de Lichtenberg C., Cheah M.H., Shevela D., Wersig J., Seuffert I., Sokaras D., Pastor E., Weninger C., Kroll T., Sierra R.G., Aller P., Butryn A., Orville A.M., Liang M., Batyuk A., Koglin J.E., Carbajo S., Boutet S., Moriarty N.W., Holton J.M., Dobbek H., Adams P.D., Bergmann U., Sauter N.K., Zouni A., Messinger J., Yano J., Yachandra V.K.
Structures of the intermediates of Kok’s photosynthetic water oxidation clock
Nature. 7731. 421-425. 10.1038/s41586-018-0681-2
Wilk P., Uehlein M., Piwowarczyk R., Dobbek H., Mueller U., Weiss M.
Structural basis for prolidase deficiency disease mechanisms
FEBS Journal. 18. 3422-3441. 10.1111/febs.14620
Keller S., Kunze C., Bommer M., Paetz C., Menezes R., Svatoš A., Dobbek H., Schubert T.
Selective utilization of benzimidazolylnorcobamides as cofactors by the tetrachloroethene reductive dehalogenase of Sulfurospirillum multivorans
Journal of Bacteriology. 8. 10.1128/JB.00584-17
Jeoung J., Dobbek H.
ATP-dependent substrate reduction at an [Fe8S9] double-cubane cluster
Proceedings of the National Academy of Sciences of the United States of America. 12. 2994-2999. 10.1073/pnas.1720489115
Sullivan B., Archibald R., Langan P.S., Dobbek H., Bommer M., McFeeters R.L., Coates L., Wang X., Gallmeier F., Carpenter J.M., Lynch V., Langan P.
Improving the accuracy and resolution of neutron crystallographic data by three-dimensional profile fitting of Bragg peaks in reciprocal space
Acta Crystallographica Section D: Structural Biology. 11. 1085-1095. 10.1107/S2059798318013347

2017

Kunze C., Bommer M., Hagen W., Uksa M., Dobbek H., Schubert T., Diekert G.
Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer
Nature Communications. 10.1038/ncomms15858
Hauf M, Richter F, Schneider T, Faidt T, Martins BM, Baumann T, Durkin P, Dobbek H, Jacobs K, Moeglich A, Budisa N
Photoactivatable Mussel-Based Underwater Adhesive Proteins by an Expanded Genetic Code
ChemBioChem. 1-6. 10.1002/cbic.201700327
Ciaccafava A., Tombolelli D., Domnik L., Jeoung J.H., Dobbek H., Mroginski M.A., Zebger I., Hildebrandt P.
Carbon Monoxide Dehydrogenase Reduces Cyanate to Cyanide
Angewandte Chemie - International Edition. 26. 7398-7401. 10.1002/anie.201703225
Domnik L., Merrouch M., Goetzl S., Jeoung J.H., Léger C., Dementin S., Fourmond V., Dobbek H.
CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2
Angewandte Chemie - International Edition. 48. 15466-15469. 10.1002/anie.201709261
Homburg C., Bommer M., Wuttge S., Hobe C., Beck S., Dobbek H., Deutscher J., Licht A., Schneider E.
Inducer exclusion in Firmicutes: insights into the regulation of a carbohydrate ATP binding cassette transporter from Lactobacillus casei BL23 by the signal transducing protein P-Ser46-HPr
Molecular Microbiology. 1. 25-45. 10.1111/mmi.13680
Schrapers P., Ilina J., Gregg C.M., Mebs S., Jeoung J.H., Dau H., Dobbek H., Haumann M.
Ligand binding at the A-cluster in full-length or truncated acetyl-CoA synthase studied by X-ray absorption spectroscopy
PLoS ONE. 2. 10.1371/journal.pone.0171039
Dobbek H.
Nitrogenase: A fuel-producing microbe
Nature Chemical Biology. 2. 134-135. 10.1038/nchembio.2288
Dobbek H.
Playing marble run to make methane
Science. 6352. 642-643. 10.1126/science.aao2439
Bommer M., Coates L., Dau H., Zouni A., Dobbek H.
Protein crystallization and initial neutron diffraction studies of the photosystem II subunit PsbO
Acta Crystallographica Section:F Structural Biology Communications. 9. 525-531
Goetzl S., Teutloff C., Werther T., Hennig S., Jeoung J., Bittl R., Dobbek H.
Protein Dynamics in the Reductive Activation of a B12-Containing Enzyme
Biochemistry. 41. 5496-5502
Werther T., Wahlefeld S., Salewski J., Kuhlmann U., Zebger I., Hildebrandt P., Dobbek H.
Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase
Nature Communications
Zhang M., Bommer M., Chatterjee R., Hussein R., Yano J., Dau H., Kern J., Dobbek H., Zouni A.
Structural insights into the light-driven auto-assembly process of the wateroxidizing Mn4CaO5-cluster in photosystem II
eLife
Wilk P., Uehlein M., Kalms J., Dobbek H., Mueller U., Weiss M.
Substrate specificity and reaction mechanism of human prolidase
FEBS Journal. 17. 2870-2885
Kielb P., Utesch T., Kozuch J., Jeoung J., Dobbek H., Mroginski M., Hildebrandt P., Weidinger I.
Switchable Redox Chemistry of the Hexameric Tyrosine-Coordinated Heme Protein
Journal of Physical Chemistry B. 16. 3955-3964

2016

Bommer M., Bondar A., Zouni A., Dobbek H., Dau H.
Crystallographic and Computational Analysis of the Barrel Part of the PsbO Protein of Photosystem II: Carboxylate-Water Clusters as Putative Proton Transfer Relays and Structural Switches
Biochemistry. 33. 4626-4635
Schrapers P., Mebs S., Goetzl S., Hennig S., Dau H., Dobbek H., Haumann M.
Axial ligation and redox changes at the cobalt ion in cobalamin bound to Corrinoid Iron-Sulfur Protein (CoFeSP) or in solution characterized by XAS and DFT
PLoS ONE. 7
Schrapers P., Mebs S., Ilina Y., Warner D., Wörmann C., Schuth N., Kositzki R., Dau H., Limberg C., Dobbek H., Haumann M.
The binuclear nickel center in the A-cluster of acetyl-CoA synthase (ACS) and two biomimetic dinickel complexes studied by X-ray absorption and emission spectroscopy
Journal of Physics: Conference Series
Young I.D., Ibrahim M., Chatterjee R., Gul S., Fuller F.D., Koroidov S., Brewster A.S., Tran R., Alonso-Mori R., Kroll T., Michels-Clark T., Laksmono H., Sierra R.G., Stan C.A., Hussein R., Zhang M., Douthit L., Kubin M., De Lichtenberg C., Vo Pham L., Nilsson H., Cheah M.H., Shevela D., Saracini C., Bean M.A., Seuffert I., Sokaras D., Weng T.C., Pastor E., Weninger C., Fransson T., Lassalle L., Bräuer P., Aller P., Docker P.T., Andi B., Orville A.M., Glownia J.M., Nelson S., Sikorski M., Zhu D., Hunter M.S., Lane T.J., Aquila A., Koglin J.E., Robinson J., Liang M., Boutet S., Lyubimov A.Y., Uervirojnangkoorn M., Moriarty N.W., Liebschner D., Afonine P.V., Waterman D.G., Evans G., Wernet P., Dobbek H., Weis W.I., Brunger A.T., Zwart P.H., Adams P.D., Zouni A., Messinger J., Bergmann U., Sauter N.K., Kern J., Yachandra V.K., Yano J.
Structure of photosystem II and substrate binding at room temperature
Nature. 7633. 453-457
Schäfer C., Bommer M., Hennig S., Jeoung J., Dobbek H., Lenz O.
Structure of an Actinobacterial-Type [NiFe]-Hydrogenase Reveals Insight into O2-Tolerant H2 Oxidation
Structure. 2. 285-292
Gregg C.M., Goetzl S., Jeoung J.H., Dobbek H.
AcsF catalyzes the ATP-dependent insertion of Nickel into the Ni, Ni-[4Fe4S] cluster of Acetyl-CoA synthase
Journal of Biological Chemistry. 35. 18129-18138
Dobbek H., Leys D.
Insights into reductive dehalogenase function obtained from crystal structures
Organohalide-Respiring Bacteria. 485-495
Ciaccafava A., Tombolelli D., Domnik L., Fesseler J., Jeoung J., Dobbek H., Mroginski M., Zebger I., Hildebrandt P.
When the inhibitor tells more than the substrate: The cyanide-bound state of a carbon monoxide dehydrogenase
Chemical Science. 5. 3162-3171
Peng L., Yarman A., Jetzschmann K., Jeoung J., Schad D., Dobbek H., Wollenberger U., Scheller F.
Molecularly imprinted electropolymer for a hexameric heme protein with direct electron transfer and peroxide electrocatalysis
Sensors (Switzerland). 3
Jeoung J., Nianios D., Fetzner S., Dobbek H.
Quercetin 2,4-Dioxygenase Activates Dioxygen in a Side-On O2-Ni Complex
Angewandte Chemie - International Edition. 10. 3281-3284

2015

Fesseler J., Jeoung J., Dobbek H.
How the [NiFe4S4] Cluster of CO Dehydrogenase Activates CO2 and NCO-
Angewandte Chemie - International Edition. 29. 8560-8564
Tanne J., Jeoung J.H., Peng L., Yarman A., Dietzel B., Schulz B., Schad D., Dobbek H., Wollenberger U., Bier F.F., Scheller F.W.
Direct Electron Transfer and Bioelectrocatalysis by a Hexameric, Heme Protein at Nanostructured Electrodes
Electroanalysis. 10. 2262-2267
Peng L., Utesch T., Yarman A., Jeoung J., Steinborn S., Dobbek H., Mroginski M., Tanne J., Wollenberger U., Scheller F.
Surface-tuned electron transfer and electrocatalysis of hexameric tyrosine-coordinated heme protein
Chemistry - A European Journal. 20. 7596-7602
Merrouch M., Hadj-Saïd J., Domnik L., Dobbek H., Léger C., Dementin S., Fourmond V.
O2 Inhibition of Ni-Containing CO Dehydrogenase Is Partly Reversible
Chemistry - A European Journal. 52. 18934-18938

2014

Hellmich J., Bommer M., Burkhardt A., Ibrahim M., Kern J., Meents A., Müh F., Dobbek H., Zouni A.
Native-like Photosystem II Superstructure at 2.44 Å Resolution through Detergent Extraction from the Protein Crystal
Structure. 11. 1607-1615
Jeoung J.H., Fesseler J., Goetzl S., Dobbek H.
Carbon monoxide. Toxic gas and fuel for anaerobes and aerobes: Carbon monoxide dehydrogenases
Metal Ions in Life Sciences. 37-69
Jeoung J., Goetzl S., Hennig S., Fesseler J., Wörmann C., Dendra J., Dobbek H.
The extended reductive acetyl-CoA pathway:ATpases in metal cluster maturation and reductive activation
Biological Chemistry. 5. 545-558
Bommer M., Kunze C., Fesseler J., Schubert T., Diekert G., Dobbek H.
Structural basis for organohalide respiration
Science. 6208. 455-458
Hennig S., Goetzl S., Jeoung J., Bommer M., Lendzian F., Hildebrandt P., Dobbek H.
ATP-induced electron transfer by redox-selective partner recognition
Nature Communications

2013

Jeoung J., Bommer M., Lin T., Dobbek H.
Visualizing the substrate-, superoxo-, alkylperoxo-, and product-bound states at the nonheme Fe(II) site of homogentisate dioxygenase
Proceedings of the National Academy of Sciences of the United States of America. 31. 12625-12630
Nehrkorn J, Martins BM, Holldack K, Stoll S, Dobbek H, Bittl R, Schnegg A
Zero-field splittings in metHb and metMb with aquo and fluoro ligands: a FD-FT THz-EPR study
Mol Phys. 2696-2707. doi:10.1080/00268976.2013.809806
Appel A., Bercaw J., Bocarsly A., Dobbek H., Dubois D., Dupuis M., Ferry J., Fujita E., Hille R., Kenis P., Kerfeld C., Morris R., Peden C., Portis A., Ragsdale S., Rauchfuss T., Reek J., Seefeldt L., Thauer R., Waldrop G.
Frontiers, opportunities, and challenges in biochemical and chemical catalysis of CO2 fixation
Chemical Reviews. 8. 6621-6658

2012

Meister W., Hennig S., Jeoung J., Lendzian F., Dobbek H., Hildebrandt P.
Complex formation with the activator RACo affects the corrinoid structure of CoFeSP
Biochemistry. 36. 7040-7042
Jeoung J., Dobbek H.
n-Butyl isocyanide oxidation at the [NiFe 4S 4OH x] cluster of CO dehydrogenase
Journal of Biological Inorganic Chemistry. 2. 167-173
Knauer S., Buckel W., Dobbek H.
On the ATP-dependent activation of the radical enzyme (R)-2- hydroxyisocaproyl-CoA dehydratase
Biochemistry. 33. 6609-6622
Buckel W, Zhang J, Friedrich P, Parthasarathy A, Li H, Djurdjevic I, Dobbek H, Martins BM
Enzyme catalyzed radical dehydrations of hydroxy acids
Biochim Biophys Acta. 1278-1290
Hennig S., Jeoung J., Goetzl S., Dobbek H.
Redox-dependent complex formation by an ATP-dependent activator of the corrinoid/iron-sulfur protein
Proceedings of the National Academy of Sciences of the United States of America. 14. 5235-5240
Jakob R., Geitner A., Weininger U., Balbach J., Dobbek H., Schmid F.
Structural and energetic basis of infection by the filamentous bacteriophage IKe
Molecular Microbiology. 6. 1124-1138
Lin T.Y., Werther T., Jeoung J.H., Dobbek H.
Suppression of electron transfer to dioxygen by charge transfer and electron transfer complexes in the FAD-dependent reductase componentof toluene dioxygenase
Journal of Biological Chemistry. 45. 38338-38346
Knauer S.H., Hartl-Spiegelhauer O., Schwarzinger S., Hänzelmann P., Dobbek H.
The Fe(II)/ α -ketoglutarate-dependent taurine dioxygenases from Pseudomonas putida and Escherichia coli are tetramers
FEBS Journal. 5. 816-831
Wuttge S., Bommer M., Jäger F., Martins B., Jacob S., Licht A., Scheffel F., Dobbek H., Schneider E.
Determinants of substrate specificity and biochemical properties of the sn-glycerol-3-phosphate ATP binding cassette transporter (UgpB-AEC2) of Escherichia coli
Molecular Microbiology. 4. 908-920

2011

Lorenz S.H., Jakob R.P., Weininger U., Balbach J., Dobbek H., Schmid F.X.
The filamentous phages fd and IF1 use different mechanisms to infect escherichia coli
Journal of Molecular Biology. 4. 989-1003
Dobbek H.
Structural aspects of mononuclear Mo/W-enzymes
Coordination Chemistry Reviews. 1104-1116
Goetzl S., Jeoung J.H., Hennig S.E., Dobbek H.
Structural basis for electron and methyl-group transfer in a methyltransferase system operating in the reductive acetyl-CoA pathway
Journal of Molecular Biology. 1. 96-109
Knauer S., Buckel W., Dobbek H.
Structural basis for reductive radical formation and electron recycling in (R)-2-hydroxyisocaproyl-CoA dehydratase
Journal of the American Chemical Society. 12. 4342-4347

2010

Jeoung J.H., Giese T., Grünwald M., Dobbek H.
Crystal structure of the ATP-dependent maturation factor of Ni,Fe-containing carbon monoxide dehydrogenases
Journal of Molecular Biology. 4. 1165-1179
Spiegelhauer O., Mende S., Dickert F., Knauer S.H., Ullmann G.M., Dobbek H.
Cysteine as a modulator residue in the active site of xenobiotic reductase A: A structural, thermodynamic and kinetic study
Journal of Molecular Biology. 1. 66-82
Spiegelhauer O., Werther T., Mende S., Knauer S.H., Dobbek H.
Determinants of Substrate Binding and Protonation in the Flavoenzyme Xenobiotic Reductase A
Journal of Molecular Biology. 2. 286-298
Jakob R.P., Zierer B.K., Weininger U., Hofmann S.D., Lorenz S.H., Balbach J., Dobbek H., Schmid F.X.
Elimination of a Cis-proline-containing loop and turn optimization stabilizes a protein and accelerates its folding
Journal of Molecular Biology. 2. 331-346

2009

Wagener N., Pierik A., Ibdah A., Hille R., Dobbek H.
The Mo-Se active site of nicotinate dehydrogenase
Proceedings of the National Academy of Sciences of the United States of America. 27. 11055-11060
Jeoung J.H., Giese T., Grünwald M., Dobbek H.
CooC1 from Carboxydothermus hydrogenoformans is a nickel-binding ATPase
Biochemistry. 48. 11505-11513
Spiegelhauer O., Dickert F., Mende S., Niks D., Hille R., Ullmann M., Dobbek H.
Kinetic characterization of xenobiotic reductase A from Pseudomonas putida 86
Biochemistry. 48. 11412-11420
Jeoung J., Dobbek H.
Structural basis of cyanide inhibition of Ni, Fe-containing carbon monoxide dehydrogenase
Journal of the American Chemical Society. 29. 9922-9923

2008

Kather I., Jakob R.P., Dobbek H., Schmid F.X.
Increased Folding Stability of TEM-1 β-Lactamase by In Vitro Selection
Journal of Molecular Biology. 1. 238-251
Dobbek H.
How biological Fe-S centers activate CO2 Wie Biologische Fe-S-Zentren CO2 Aktivieren
Nachrichten aus der Chemie. 734-737
Kather I., Jakob R., Dobbek H., Schmid F.X.
Changing the Determinants of Protein Stability from Covalent to Non-Covalent Interactions by In Vitro Evolution: A Structural and Energetic Analysis
Journal of Molecular Biology. 4. 1040-1054

2007

Jeoung J.H., Dobbek H.
Carbon dioxide activation at the Ni,Fe-cluster of anaerobic carbon monoxide dehydrogenase
Science. 5855. 1461-1464
Zoldák G., Redecke L., Svergun D.I., Konarev P.V., Voertler C.S., Dobbek H., Sedlák E., Sprinzl M.
Release factors 2 from Escherichia coli and Thermus thermophilus: Structural, spectroscopic and microcalorimetric studies
Nucleic Acids Research. 4. 1343-1353
Einsle O., Andrade S., Dobbek H., Meyer J., Rees D.
Assignment of individual metal redox states in a metalloprotein by crystallographic refinement at multiple X-ray wavelengths
Journal of the American Chemical Society. 8. 2210-2211
Jeoung J, Pippig DA, Martins BM, Wagener N, Dobbek H
HTHP: a novel class of hexameric, tyrosine-coordinated heme proteins
Journal of Molecular Biology. 4. 1122{--}1131

2006

Svetlitchnaia T., Svetlitchnyi V., Meyer O., Dobbek H.
Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis
Proceedings of the National Academy of Sciences of the United States of America. 39. 14331-14336
Griese J.J., P. Jakob R., Schwarzinger S., Dobbek H.
Xenobiotic Reductase A in the Degradation of Quinoline by Pseudomonas putida 86: Physiological Function, Structure and Mechanism of 8-Hydroxycoumarin Reduction
Journal of Molecular Biology. 1. 140-152

2005

Martins B., Svetlitchnaia T., Dobbek H.
2-Oxoquinoline 8-monooxygenase oxygenase component: Active site modulation by Rieske-[2Fe-2S] center oxidation/reduction
Structure. 5. 817-824
Resch M., Dobbek H., Meyer O.
Structural and functional reconstruction in situ of the [CuSMoO 2] active site of carbon monoxide dehydrogenase from the carbon monoxide oxidizing eubacterium Oligotropha carboxidovorans
Journal of Biological Inorganic Chemistry. 5. 518-528

2004

Bonin I, Martins BM, Puranov V, Fetzner S, Huber R, Dobbek H
Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase
Structure. 8. 1425{--}1435
Svetlitchnyi V., Dobbek H., Meyer-Klaucke W., Meins T., Thiele B., Römer P., Huber R., Meyer O.
A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans
Proceedings of the National Academy of Sciences of the United States of America. 2. 446-451
Martins B., Dobbek H., Çinkaya I., Buckel W., Messerschmidt A.
Crystal structure of 4-hydroxybutyryl-CoA dehydratase: Radical catalysis involving a [4Fe-4S] cluster and flavin
Proceedings of the National Academy of Sciences of the United States of America. 44. 15645-15649
Dobbek H., Svetlitchnyi V., Liss J., Meyer O.
Carbon Monoxide Induced Decomposition of the Active Site [Ni-4Fe-5S] Cluster of CO Dehydrogenase
Journal of the American Chemical Society. 17. 5382-5387

2002

Dobbek H., Gremer L., Kiefersauer R., Huber R., Meyer O.
Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-Å resolution
Proceedings of the National Academy of Sciences of the United States of America. 25. 15971-15976
Dobbek H., Huber R.
The molybdenum and tungsten cofactors: A crystallographic view
Metals Ions in Biological System: Molybdenum and Tungsten: Their Roles in Biological Processes. 227-263

2001

Dobbek H., Svetlitchnyi V., Gremer L., Huber R., Meyer O.
Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster
Science. 5533. 1281-1285

2000

Meyer O., Gremer L., Ferner R., Ferner M., Dobbek H., Gnida M., Meyer-Klaucke W., Huber R.
The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase
Biological Chemistry. 865-876
Kiefersauer R., Than M.E., Dobbek H., Gremer L., Melero M., Strobl S., Dias J.M., Soulimane T., Huber R.
A novel free-mounting system for protein crystals: Transformation and improvement of diffraction power by accurately controlled humidity changes
Journal of Applied Crystallography. 5. 1223-1230
Gremer L., Kellner S., Dobbek H., Huber R., Meyer O.
Binding of flavin adenine dinucleotide to molybdenum-containing carbon monoxide dehydrogenase from Oligotropha carboxidovorans. Structural and functional analysis of a carbon monoxide dehydrogenase species in which the native flavoprotein has been replaced by its recombinant counterpart produced in Escherichia coli
Journal of Biological Chemistry. 3. 1864-1872
Hänzelmann P., Dobbek H., Gremer L., Huber R., Meyer O.
The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase
Journal of Molecular Biology. 5. 1221-1235

1999

Dobbek H., Gremer L., Meyer O., Huber R.
Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine
Proceedings of the National Academy of Sciences of the United States of America. 16. 8884-8889

1997

Knäblein J., Dobbek H., Ehlert S., Schneider F.
Isolation, Cloning, Sequence Analysis and X-Ray Structure of Dimethyl Sulfoxide/Trimethylamine N-Oxide Reductase from Rhodobactercapsulatus
Biological Chemistry. 293-302
Knäblein J., Dobbek H., Schneider F.
Organization of the DMSO Respiratory Operon of Rhodobactercapsulatus and Its Consequences for Homologous Expression of DMSOR/TMAOR
Biological Chemistry. 303-308