Humboldt-Universität zu Berlin - Structural Biology / Biochemistry

Structural Biology and Biochemistry of Metalloenzymes


Research focus: Bacteria and Archaea can use carbon monoxide (CO), carbon dioxide (CO2), and numerous pollutants as carbon and/or energy sources. To activate and convert these inert compounds, the organisms use complex metalloenzymes that catalyze reactions under mild cellular conditions. For comparison, in a chemistry laboratory, similar reactions are only possible with valuable catalysts under high pressure and temperatures. How these metal-containing enzymes achieve this feast is hardly understood. 
We use protein crystallography in combination with protein chemistry and molecular biology to study molecular energy conversions.
Our goals are to better understand the molecular basis of catalytic processes and the evolution of enzymes. Our long-term goal is to evolve new (bio)catalysts for the energy-efficient use of CO2 and CO, as well as for the (bio)degradation of pollutants.


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Current research areas:


Previous projects:
How are aromatic compounds degraded? 
How do enzymes generate radical intermediates?

Humboldt-Universität zu Berlin
Lebenswissenschaftliche Fakultät, Institut für Biologie
Prof. Dr. Holger Dobbek
Philippstr. 13, Leonor Michaelis Haus (Haus 18)
10115 Berlin


Tel: +49 30 2093 49840