Structural basis for coupled ATP-driven electron transfer in the double-cubane cluster protein (PNAS, June '22)
Jae-Hun Jeoung, Sabine Nicklisch and Holger Dobbek conducted binding and kinetics studies in tandem with X-ray crystallography to investigate the spatial arrangements of functional elements necessary for ATP-dependent electron transfer. Striking similarities with the non-homologous nitrogenases suggest a convergent evolution of catalytic strategies to achieve ATP-driven electron transfers between iron-sulphur clusters.
Jae-Hun Jeoung, Sabine Nicklisch and Holger Dobbek (2022) PNAS, 119, e2203576119, DOI:10.1073/pnas.2203576119