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Humboldt-Universität zu Berlin - Mikrobiologie

20 key publications


Pfiffer, V., O. Sarenko, A. Possling, and R. Hengge (2019) Genetic dissection of Escherichia coli's master diguanylate cyclase DgcE: Role of the N-terminal MASE1 domain and direct signal input from a GTPase partner system. PLoS Genet., 15(4): e1008059. doi:10.1371/journal.pgen.1008059.

[PLoS Genet.]


Serra, D.O. and Regine Hengge (2019) A c-di-GMP-Based Switch Controls Local Heterogeneity of Extracellular Matrix Synthesis which Is Crucial for Integrity and Morphogenesis of Escherichia coli Macrocolony Biofilms. J. Mol. Biol. doi: 10.1016/j.jmb.2019.04.001.


Klauck, G., D.O. Serra, A. Possling, and R. Hengge (2018) Spatial organisation of different sigma factor activities and c-di-GMP signalling within the 3D landscape of a bacterial biofilm. Open Biol. 8: 180066. doi: 10.1098/rsob.180066.


Herbst, S., M. Lorkowski, O. Sarenko, T.K.L. Nguyen, T. Jaenicke, and R. Hengge (2018) Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP phosphodiesterase. EMBO J. 37: e97825. doi: 10.15252/embj.201797825.


Thongsomboon, W., D.O. Serra, A. Possling, C. Hadjineophytou, R. Hengge and L. Cegelski (2018) Phosphoethanolamine cellulose: a naturally produced chemically modified cellulose. Science 359: 334-338. doi: 10.1126/science.aao4096.

Highlighted by:

(1) Galperin, M.Y. and D.N. Shalaeva (2018) A bacterial coat that is not pure cotton. Science 359: 276-277.

(2) Nature highlights: How bacteria make their fortresses. https://www.nature.com/articles/ d41586-018-00977-8 (Jan 18, 2018)

(3) Hamers, L.: The secret to icky, sticky bacterial biofilms lies in the microbes´ cellulose. Science News. https://www.sciencenews.org/article/secret-bacterial-biofilms-microbes-modified-cellulose?tgt=nr (Jan 18, 2018)

(4) Yirka, B.: Bacterial biofilm cellulose found to differ from plant cellulose. Phys.Org. https://phys.org/news/2018-01-bacterial-biofilm-cellulose-differ.html (Jan 19, 2018)

(5) Arnaud, C.H.: Bacteria can make modified cellulose. Chem. Engin. News 96: 8. https://cen.acs.org/articles/96/i4/Bacteria-make-modified-cellulose.html?type=paidArticleContent (Jan 22, 2018)

(6) Golden, M.: Stanford-led team discovers new cellulose that could have applications from energy to medicine. Stanford News Service (Jan 19, 2018)

(7) Forschungsteam schafft neue Möglichkeiten für Medizin und Materialwissenschaft. Humboldt-Universität zu Berlin, Presseportal (Jan 23, 2018)

(8) Nester, G.: In F1000Prime, 12 February 2018. DOI: 10.3410/f.732501572.793542371

(9) Whitfield, C.: In F1000Prime, 16 February 2018. DOI: 10.3410/f.732501572.793542459


Sarenko, O., G. Klauck, F.M. Wilke, V. Pfiffer, A.M. Richter, S. Herbst, V. Kaever, and R. Hengge (2017) More than enzymes that make and break c-di-GMP - the protein interaction network of GGDEF/EAL domain proteins of Escherichia coli. mBio 8, e01639-17. doi: 10.1128/mBio.01639-17.

Highlighted in Faculty of 1000s:

(1) Sondermann H: In F1000Prime, 19 October 2017. DOI: 10.3410/f.731966577.793537737;

(2) Galperin M: In F1000Prime, 20 October 2017. DOI:10.3410/f. 731966577.793537754.


Serra, D.O., F. Mika, A.M. Richter, and R. Hengge (2016) The green tea polyphenol EGCG inhibits E. coli biofilm formation by impairing amyloid curli fibre assembly and downregulating the biofilm regulator CsgD via the σE-dependent sRNA RybB. Mol. Microbiol., 101, 136–151. doi:10.1111/mmi.13379.


Povolotsky, T. and R. Hengge (2015) Genome-Based Comparison of Cyclic Di-GMP Signaling in Pathogenic and Commensal Escherichia coli Strains. J. Bacteriol. 198,111-26. doi: 10.1128/JB.00520-15.


Richter, A.M., T.L. Povolotsky, L.H. Wieler, and R. Hengge (2014) C-di-GMP signaling and biofilm-related properties of the Shiga toxin-producing 2011 German outbreak Escherichia coli O104:H4. EMBO Mol. Med. 6, 1622-1637. doi: 10.15252/emmm.201404309


Lindenberg, S., G. Klauck, C. Pesavento, E. Klauck, and R. Hengge (2013) The EAL protein YciR is a trigger enzyme in a c-di-GMP signaling cascade in E. coli biofilm control. EMBO J. 32, 2001-2014. doi:10.1038/emboj.2013.120

Highlighted in EMBO J: Jenal, U. (2013) Think globally, act locally: How bacteria integrate local decisions with their global cellular programme. EMBO J. 32, 1972-1974;

Highlighted in Faculty of 1000s: Sondermann H: In F1000Prime, 31 May 2013; F1000Prime.com/718014183#eval793477187.


Serra, D.O., A.M. Richter, and R. Hengge (2013) Cellulose as an architectural element in spatially structured Escherichia coli biofilms. J. Bacteriol. 195, 5540-5554. doi: 10.1128/JB.00946-13.


Pesavento, C., and R. Hengge (2012) The global repressor FliZ antagonizes gene expression by σs–containing RNA polymerase due to overlapping DNA binding specificity. Nucl. Acids Res. 40, 4783-4793. doi: 10.1093/nar/gks055


Hengge, R. (2009) Principles of cyclic-di-GMP signaling. Nature Rev. Microbiol. 7, 263-273.


Tschowri, N., S. Busse, and R. Hengge (2009) The BLUF-EAL protein YcgF acts as a direct anti-repressor in a blue light stress response of E.coli. Genes Dev. 23, 522-534.


Pesavento, C., G. Becker, N. Sommerfeldt, A. Possling, N. Tschowri, A. Mehlis, and R. Hengge (2008) Inverse regulatory coordination of motility and curli-mediated adhesion of E. coli. Genes Dev. 22, 2434-2446.


Typas, A., G. Becker, and R. Hengge (2007) The molecular basis of selective promoter activation by the σs subunit of RNA polymerase. Mol. Microbiol. 63, 1296-1306.


Typas, A., C. Barembruch, A. Possling, and R. Hengge (2007) Stationary phase reorganisation of the E. coli transcription machinery by Crl protein, a fine-tuner of σs activity and levels. EMBO J. 26, 1569-1578.


Becker, G., E. Klauck, and R. Hengge-Aronis (1999) Regulation of RpoS (σs) proteolysis in Escherichia coli: The response regulator RssB is a recognition factor that interacts with the turnover element in RpoS. Proc. Natl. Acad. Sci. USA 96, 6439-6444.


Muffler, A., D. Fischer, and R. Hengge-Aronis (1996) The RNA-binding protein HF-I, known as a host factor for phage Qb RNA replication, is essential for the translational regulation of rpoS in Escherichia coli. Genes Dev. 10, 1143-1151.


Muffler, A., D. Fischer, S. Altuvia, G. Storz, and R. Hengge-Aronis (1996) The response regulator RssB controls stability of the σs subunit of RNA-polymerase in Escherichia coli. EMBO J. 15, 1333-1339.


Lange, R. and R. Hengge-Aronis (1994) The cellular concentration of the σs subunit of RNA-polymerase in Escherichia coli is controlled at the levels of transcription, translation and protein stability. Genes Dev. 8, 1600-1612.


Lange, R. and R. Hengge-Aronis (1991) Identification of a central regulator of stationary phase gene expression in Escherichia coli. Mol. Microbiol. 5, 49-59.